Gait pattern in Duchenne muscular dystrophy

Maria Grazia D'Angelo, Matteo Berti, Luigi Piccinini, Marianna Romei, Michela Guglieri, Sara Bonato, Alessandro Degrate, Anna Carla Turconi, Nereo Bresolin

Research output: Contribution to journalArticle

Abstract

We investigated the gait pattern of 21 patients with Duchenne muscular dystrophy (DMD), compared to 10 healthy controls through 3D Gait Analysis. An overall observation of gait pattern in our DMD patients when compared to controls confirmed the data previously reported for small dystrophic groups. An excessive anterior tilt of pelvis and abnormal knee pattern in loading response phase were found. Since during the swing phase the DMD foot is too plantarflexed, patients adopt a higher flexion and abduction of the hip in order to advance the swinging limb. Velocity and cadence of DMD patients resulted similar to those calculated for healthy subjects, whereas stride length was reduced and step width was increased. We then divided the DMD patients in to two subgroups (treated with steroids and untreated), and we observed that the only statistically significant differences between the two groups in Gait Analysis parameters were found for the maximum of ankle power. 3D Gait Analysis gives objective and quantitative information about the gait pattern and the deviations due to muscular situation of DMD subjects; being our study a single moment evaluation, it is otherwise unable to unravel changes only detectable through serial analysis during the time course of the disease and, if any, due to the treatment.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalGait and Posture
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

Duchenne Muscular Dystrophy
Gait
Pelvis
Ankle
Hip
Foot
Knee
Healthy Volunteers
Extremities
Steroids
Observation

Keywords

  • Ambulation
  • Biomechanics
  • Duchenne muscular dystrophy
  • Gait Analysis
  • Steroids treatment

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Rehabilitation

Cite this

Gait pattern in Duchenne muscular dystrophy. / D'Angelo, Maria Grazia; Berti, Matteo; Piccinini, Luigi; Romei, Marianna; Guglieri, Michela; Bonato, Sara; Degrate, Alessandro; Turconi, Anna Carla; Bresolin, Nereo.

In: Gait and Posture, Vol. 29, No. 1, 01.2009, p. 36-41.

Research output: Contribution to journalArticle

D'Angelo, MG, Berti, M, Piccinini, L, Romei, M, Guglieri, M, Bonato, S, Degrate, A, Turconi, AC & Bresolin, N 2009, 'Gait pattern in Duchenne muscular dystrophy', Gait and Posture, vol. 29, no. 1, pp. 36-41. https://doi.org/10.1016/j.gaitpost.2008.06.002
D'Angelo, Maria Grazia ; Berti, Matteo ; Piccinini, Luigi ; Romei, Marianna ; Guglieri, Michela ; Bonato, Sara ; Degrate, Alessandro ; Turconi, Anna Carla ; Bresolin, Nereo. / Gait pattern in Duchenne muscular dystrophy. In: Gait and Posture. 2009 ; Vol. 29, No. 1. pp. 36-41.
@article{c64bdcfa30eb4cb28d80dc8744f01c24,
title = "Gait pattern in Duchenne muscular dystrophy",
abstract = "We investigated the gait pattern of 21 patients with Duchenne muscular dystrophy (DMD), compared to 10 healthy controls through 3D Gait Analysis. An overall observation of gait pattern in our DMD patients when compared to controls confirmed the data previously reported for small dystrophic groups. An excessive anterior tilt of pelvis and abnormal knee pattern in loading response phase were found. Since during the swing phase the DMD foot is too plantarflexed, patients adopt a higher flexion and abduction of the hip in order to advance the swinging limb. Velocity and cadence of DMD patients resulted similar to those calculated for healthy subjects, whereas stride length was reduced and step width was increased. We then divided the DMD patients in to two subgroups (treated with steroids and untreated), and we observed that the only statistically significant differences between the two groups in Gait Analysis parameters were found for the maximum of ankle power. 3D Gait Analysis gives objective and quantitative information about the gait pattern and the deviations due to muscular situation of DMD subjects; being our study a single moment evaluation, it is otherwise unable to unravel changes only detectable through serial analysis during the time course of the disease and, if any, due to the treatment.",
keywords = "Ambulation, Biomechanics, Duchenne muscular dystrophy, Gait Analysis, Steroids treatment",
author = "D'Angelo, {Maria Grazia} and Matteo Berti and Luigi Piccinini and Marianna Romei and Michela Guglieri and Sara Bonato and Alessandro Degrate and Turconi, {Anna Carla} and Nereo Bresolin",
year = "2009",
month = "1",
doi = "10.1016/j.gaitpost.2008.06.002",
language = "English",
volume = "29",
pages = "36--41",
journal = "Gait and Posture",
issn = "0966-6362",
publisher = "Elsevier B.V.",
number = "1",

}

TY - JOUR

T1 - Gait pattern in Duchenne muscular dystrophy

AU - D'Angelo, Maria Grazia

AU - Berti, Matteo

AU - Piccinini, Luigi

AU - Romei, Marianna

AU - Guglieri, Michela

AU - Bonato, Sara

AU - Degrate, Alessandro

AU - Turconi, Anna Carla

AU - Bresolin, Nereo

PY - 2009/1

Y1 - 2009/1

N2 - We investigated the gait pattern of 21 patients with Duchenne muscular dystrophy (DMD), compared to 10 healthy controls through 3D Gait Analysis. An overall observation of gait pattern in our DMD patients when compared to controls confirmed the data previously reported for small dystrophic groups. An excessive anterior tilt of pelvis and abnormal knee pattern in loading response phase were found. Since during the swing phase the DMD foot is too plantarflexed, patients adopt a higher flexion and abduction of the hip in order to advance the swinging limb. Velocity and cadence of DMD patients resulted similar to those calculated for healthy subjects, whereas stride length was reduced and step width was increased. We then divided the DMD patients in to two subgroups (treated with steroids and untreated), and we observed that the only statistically significant differences between the two groups in Gait Analysis parameters were found for the maximum of ankle power. 3D Gait Analysis gives objective and quantitative information about the gait pattern and the deviations due to muscular situation of DMD subjects; being our study a single moment evaluation, it is otherwise unable to unravel changes only detectable through serial analysis during the time course of the disease and, if any, due to the treatment.

AB - We investigated the gait pattern of 21 patients with Duchenne muscular dystrophy (DMD), compared to 10 healthy controls through 3D Gait Analysis. An overall observation of gait pattern in our DMD patients when compared to controls confirmed the data previously reported for small dystrophic groups. An excessive anterior tilt of pelvis and abnormal knee pattern in loading response phase were found. Since during the swing phase the DMD foot is too plantarflexed, patients adopt a higher flexion and abduction of the hip in order to advance the swinging limb. Velocity and cadence of DMD patients resulted similar to those calculated for healthy subjects, whereas stride length was reduced and step width was increased. We then divided the DMD patients in to two subgroups (treated with steroids and untreated), and we observed that the only statistically significant differences between the two groups in Gait Analysis parameters were found for the maximum of ankle power. 3D Gait Analysis gives objective and quantitative information about the gait pattern and the deviations due to muscular situation of DMD subjects; being our study a single moment evaluation, it is otherwise unable to unravel changes only detectable through serial analysis during the time course of the disease and, if any, due to the treatment.

KW - Ambulation

KW - Biomechanics

KW - Duchenne muscular dystrophy

KW - Gait Analysis

KW - Steroids treatment

UR - http://www.scopus.com/inward/record.url?scp=57649150076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57649150076&partnerID=8YFLogxK

U2 - 10.1016/j.gaitpost.2008.06.002

DO - 10.1016/j.gaitpost.2008.06.002

M3 - Article

C2 - 18656361

AN - SCOPUS:57649150076

VL - 29

SP - 36

EP - 41

JO - Gait and Posture

JF - Gait and Posture

SN - 0966-6362

IS - 1

ER -