Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type and Down syndrome

Chiara Rigoldi, Manuela Galli, Veronica Cimolin, Filippo Camerota, Claudia Celletti, Nunzio Tenore, Giorgio Albertini

Research output: Contribution to journalArticle

Abstract

People suffering from Ehlers-Danlos syndrome (EDS) hypermobility type present a severe ligament laxity that results in difficulties in muscle force transmission. The same condition is present in people suffering from Down syndrome (DS) even if their clumsy movements are due to cerebral and cognitive impairments. The aim of this study was to quantify the gait patterns of subjects with EDS and with DS using Gait Analysis (GA). We quantified the gait strategy in 12 EDS individuals and in 16 participants with DS. Both pathological groups were compared to 20 age-matched healthy controls in terms of kinematics and kinetics. Results showed that DS individuals are characterized by a more compromised gait pattern than EDS participants, even if both groups are characterized by joint hypermobility. All the patients showed significant decreased of ankle stiffness probably due to congenital hypotonia and ligament laxity, while different values of hip stiffness. These findings help to elucidate the complex biomechanical changes due to joint hypermobility and may have a major role in the multidimensional evaluation and tailored management of these patients.

Original languageEnglish
Pages (from-to)1437-1442
Number of pages6
JournalResearch in Developmental Disabilities
Volume33
Issue number5
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Down Syndrome
Ehlers-Danlos Syndrome
Gait
Joint Instability
Ligaments
Muscle Hypotonia
Biomechanical Phenomena
Ankle
Hip
Muscles
Ehlers-Danlos syndrome type 3

Keywords

  • Down syndrome
  • Ehlers-Danlos syndrome
  • Gait analysis
  • Ligament laxity

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology

Cite this

Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type and Down syndrome. / Rigoldi, Chiara; Galli, Manuela; Cimolin, Veronica; Camerota, Filippo; Celletti, Claudia; Tenore, Nunzio; Albertini, Giorgio.

In: Research in Developmental Disabilities, Vol. 33, No. 5, 09.2012, p. 1437-1442.

Research output: Contribution to journalArticle

Rigoldi, Chiara ; Galli, Manuela ; Cimolin, Veronica ; Camerota, Filippo ; Celletti, Claudia ; Tenore, Nunzio ; Albertini, Giorgio. / Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type and Down syndrome. In: Research in Developmental Disabilities. 2012 ; Vol. 33, No. 5. pp. 1437-1442.
@article{4166ba16b0e24bc7b78f392504003d82,
title = "Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type and Down syndrome",
abstract = "People suffering from Ehlers-Danlos syndrome (EDS) hypermobility type present a severe ligament laxity that results in difficulties in muscle force transmission. The same condition is present in people suffering from Down syndrome (DS) even if their clumsy movements are due to cerebral and cognitive impairments. The aim of this study was to quantify the gait patterns of subjects with EDS and with DS using Gait Analysis (GA). We quantified the gait strategy in 12 EDS individuals and in 16 participants with DS. Both pathological groups were compared to 20 age-matched healthy controls in terms of kinematics and kinetics. Results showed that DS individuals are characterized by a more compromised gait pattern than EDS participants, even if both groups are characterized by joint hypermobility. All the patients showed significant decreased of ankle stiffness probably due to congenital hypotonia and ligament laxity, while different values of hip stiffness. These findings help to elucidate the complex biomechanical changes due to joint hypermobility and may have a major role in the multidimensional evaluation and tailored management of these patients.",
keywords = "Down syndrome, Ehlers-Danlos syndrome, Gait analysis, Ligament laxity",
author = "Chiara Rigoldi and Manuela Galli and Veronica Cimolin and Filippo Camerota and Claudia Celletti and Nunzio Tenore and Giorgio Albertini",
year = "2012",
month = "9",
doi = "10.1016/j.ridd.2012.03.016",
language = "English",
volume = "33",
pages = "1437--1442",
journal = "Research in Developmental Disabilities",
issn = "0891-4222",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type and Down syndrome

AU - Rigoldi, Chiara

AU - Galli, Manuela

AU - Cimolin, Veronica

AU - Camerota, Filippo

AU - Celletti, Claudia

AU - Tenore, Nunzio

AU - Albertini, Giorgio

PY - 2012/9

Y1 - 2012/9

N2 - People suffering from Ehlers-Danlos syndrome (EDS) hypermobility type present a severe ligament laxity that results in difficulties in muscle force transmission. The same condition is present in people suffering from Down syndrome (DS) even if their clumsy movements are due to cerebral and cognitive impairments. The aim of this study was to quantify the gait patterns of subjects with EDS and with DS using Gait Analysis (GA). We quantified the gait strategy in 12 EDS individuals and in 16 participants with DS. Both pathological groups were compared to 20 age-matched healthy controls in terms of kinematics and kinetics. Results showed that DS individuals are characterized by a more compromised gait pattern than EDS participants, even if both groups are characterized by joint hypermobility. All the patients showed significant decreased of ankle stiffness probably due to congenital hypotonia and ligament laxity, while different values of hip stiffness. These findings help to elucidate the complex biomechanical changes due to joint hypermobility and may have a major role in the multidimensional evaluation and tailored management of these patients.

AB - People suffering from Ehlers-Danlos syndrome (EDS) hypermobility type present a severe ligament laxity that results in difficulties in muscle force transmission. The same condition is present in people suffering from Down syndrome (DS) even if their clumsy movements are due to cerebral and cognitive impairments. The aim of this study was to quantify the gait patterns of subjects with EDS and with DS using Gait Analysis (GA). We quantified the gait strategy in 12 EDS individuals and in 16 participants with DS. Both pathological groups were compared to 20 age-matched healthy controls in terms of kinematics and kinetics. Results showed that DS individuals are characterized by a more compromised gait pattern than EDS participants, even if both groups are characterized by joint hypermobility. All the patients showed significant decreased of ankle stiffness probably due to congenital hypotonia and ligament laxity, while different values of hip stiffness. These findings help to elucidate the complex biomechanical changes due to joint hypermobility and may have a major role in the multidimensional evaluation and tailored management of these patients.

KW - Down syndrome

KW - Ehlers-Danlos syndrome

KW - Gait analysis

KW - Ligament laxity

UR - http://www.scopus.com/inward/record.url?scp=84860522215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860522215&partnerID=8YFLogxK

U2 - 10.1016/j.ridd.2012.03.016

DO - 10.1016/j.ridd.2012.03.016

M3 - Article

C2 - 22522202

AN - SCOPUS:84860522215

VL - 33

SP - 1437

EP - 1442

JO - Research in Developmental Disabilities

JF - Research in Developmental Disabilities

SN - 0891-4222

IS - 5

ER -