Galactosylhydroxylysine and pyridinium cross links in monitoring the bone response to hormone replacement therapy

R. Marabini, P. Sirtori, R. Chionna, L. Barzizza, A. Rubinacci

Research output: Contribution to journalArticlepeer-review

Abstract

Aim of the study was to compare urinary galactosyl-hydroxylysine (GHyl), deoxypyridinoline (D-Pyr) and pyridinoline (Pyr) before and after 5 to 9 months of hormone replacement therapy (HRT) in postmenopausal women. The urinary markers were measured by HPLC in the second void of fasting samples and were expressed as ratio to creatinine. GHyl was also expressed as a ratio to glucosylgalactolysyl-hydroxylysine (GGHyl). After short-term hormone replacement therapy, urinary D-Pyr fell significantly, but Pyr and GHyl, also when expressed as a ratio to GGHyl, remained unmodified. We conclude that GHyl and Pyr are not useful markers in monitoring the bone response to HRT in postmenopausal women.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalJournal of Endocrinological Investigation
Volume19
Issue number3
Publication statusPublished - Mar 1996

Keywords

  • Bone remodeling
  • Glycosides
  • Hormone replacement therapy
  • Pyridinium cross-links

ASJC Scopus subject areas

  • Endocrinology

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