Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease

Alfredo Costa, Paola Bini, Maria Hamze-Sinno, Arrigo Moglia, Diego Franciotta, Elena Sinforiani, Sabrina Ravaglia, Christine Bole-Feysot, Tomas Hökfelt, Pierre Déchelotte, Serguei O. Fetissov

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Neuropeptides galanin and α-melanocyte-stimulating hormone (α-MSH) are involved in the regulation of memory and appetite. Increased galanin and decreased α-MSH levels were reported in postmortem brains of patients with Alzheimer's disease (AD) but the underlying mechanisms are uncertain. Here we studied if autoantibodies (autoAbs) reacting with galanin and α-MSH are altered in AD. Methods: Levels of free and total IgG autoAbs reacting with galanin and α-MSH were measured in sera and cerebrospinal fluid (CSF) of 18 subjects with AD and in 15 age-matched non-demented controls. Values were correlated with Mini-Mental State Examination (MMSE) score, body mass index (BMI) and CSF levels of AD biomarkers. Results: CSF levels of total but not free IgG autoAbs against galanin were increased in AD, resulting in increased percentage of galanin autoAbs present as immune complexes. CSF levels of galanin total autoAbs and α-MSH free autoAbs correlated negatively with the severity of cognitive impairment as measured by MMSE. Both total and free autoAbs against galanin and α-MSH in CSF correlated negatively with age in AD patients but not in controls. CSF levels of galanin autoAbs and free α-MSH AutoAbs negatively correlated with CSF levels of t-Tau, p-Tau and ratios of t-Tau/Aβ42 or p-Tau/Aβ42 in AD patients but not in controls. Conclusions: AutoAbs reacting with galanin and α-MSH are present in CSF and are associated with clinical characteristics of AD patients. The functional significance and therapeutic potential of these autoAbs should be further clarified.

Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalJournal of Neuroimmunology
Volume240-241
DOIs
Publication statusPublished - Dec 15 2011

Fingerprint

Melanocyte-Stimulating Hormones
Galanin
Autoantibodies
Cerebrospinal Fluid
Alzheimer Disease
Immunoglobulin G
Appetite Regulation
Antigen-Antibody Complex
Neuropeptides
Body Mass Index
Biomarkers

Keywords

  • α-MSH
  • Alzheimer's disease
  • Autoantibodies
  • CSF
  • Galanin
  • Neurodegeneration

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease. / Costa, Alfredo; Bini, Paola; Hamze-Sinno, Maria; Moglia, Arrigo; Franciotta, Diego; Sinforiani, Elena; Ravaglia, Sabrina; Bole-Feysot, Christine; Hökfelt, Tomas; Déchelotte, Pierre; Fetissov, Serguei O.

In: Journal of Neuroimmunology, Vol. 240-241, 15.12.2011, p. 114-120.

Research output: Contribution to journalArticle

Costa, A, Bini, P, Hamze-Sinno, M, Moglia, A, Franciotta, D, Sinforiani, E, Ravaglia, S, Bole-Feysot, C, Hökfelt, T, Déchelotte, P & Fetissov, SO 2011, 'Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease', Journal of Neuroimmunology, vol. 240-241, pp. 114-120. https://doi.org/10.1016/j.jneuroim.2011.10.003
Costa, Alfredo ; Bini, Paola ; Hamze-Sinno, Maria ; Moglia, Arrigo ; Franciotta, Diego ; Sinforiani, Elena ; Ravaglia, Sabrina ; Bole-Feysot, Christine ; Hökfelt, Tomas ; Déchelotte, Pierre ; Fetissov, Serguei O. / Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease. In: Journal of Neuroimmunology. 2011 ; Vol. 240-241. pp. 114-120.
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T1 - Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease

AU - Costa, Alfredo

AU - Bini, Paola

AU - Hamze-Sinno, Maria

AU - Moglia, Arrigo

AU - Franciotta, Diego

AU - Sinforiani, Elena

AU - Ravaglia, Sabrina

AU - Bole-Feysot, Christine

AU - Hökfelt, Tomas

AU - Déchelotte, Pierre

AU - Fetissov, Serguei O.

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N2 - Background: Neuropeptides galanin and α-melanocyte-stimulating hormone (α-MSH) are involved in the regulation of memory and appetite. Increased galanin and decreased α-MSH levels were reported in postmortem brains of patients with Alzheimer's disease (AD) but the underlying mechanisms are uncertain. Here we studied if autoantibodies (autoAbs) reacting with galanin and α-MSH are altered in AD. Methods: Levels of free and total IgG autoAbs reacting with galanin and α-MSH were measured in sera and cerebrospinal fluid (CSF) of 18 subjects with AD and in 15 age-matched non-demented controls. Values were correlated with Mini-Mental State Examination (MMSE) score, body mass index (BMI) and CSF levels of AD biomarkers. Results: CSF levels of total but not free IgG autoAbs against galanin were increased in AD, resulting in increased percentage of galanin autoAbs present as immune complexes. CSF levels of galanin total autoAbs and α-MSH free autoAbs correlated negatively with the severity of cognitive impairment as measured by MMSE. Both total and free autoAbs against galanin and α-MSH in CSF correlated negatively with age in AD patients but not in controls. CSF levels of galanin autoAbs and free α-MSH AutoAbs negatively correlated with CSF levels of t-Tau, p-Tau and ratios of t-Tau/Aβ42 or p-Tau/Aβ42 in AD patients but not in controls. Conclusions: AutoAbs reacting with galanin and α-MSH are present in CSF and are associated with clinical characteristics of AD patients. The functional significance and therapeutic potential of these autoAbs should be further clarified.

AB - Background: Neuropeptides galanin and α-melanocyte-stimulating hormone (α-MSH) are involved in the regulation of memory and appetite. Increased galanin and decreased α-MSH levels were reported in postmortem brains of patients with Alzheimer's disease (AD) but the underlying mechanisms are uncertain. Here we studied if autoantibodies (autoAbs) reacting with galanin and α-MSH are altered in AD. Methods: Levels of free and total IgG autoAbs reacting with galanin and α-MSH were measured in sera and cerebrospinal fluid (CSF) of 18 subjects with AD and in 15 age-matched non-demented controls. Values were correlated with Mini-Mental State Examination (MMSE) score, body mass index (BMI) and CSF levels of AD biomarkers. Results: CSF levels of total but not free IgG autoAbs against galanin were increased in AD, resulting in increased percentage of galanin autoAbs present as immune complexes. CSF levels of galanin total autoAbs and α-MSH free autoAbs correlated negatively with the severity of cognitive impairment as measured by MMSE. Both total and free autoAbs against galanin and α-MSH in CSF correlated negatively with age in AD patients but not in controls. CSF levels of galanin autoAbs and free α-MSH AutoAbs negatively correlated with CSF levels of t-Tau, p-Tau and ratios of t-Tau/Aβ42 or p-Tau/Aβ42 in AD patients but not in controls. Conclusions: AutoAbs reacting with galanin and α-MSH are present in CSF and are associated with clinical characteristics of AD patients. The functional significance and therapeutic potential of these autoAbs should be further clarified.

KW - α-MSH

KW - Alzheimer's disease

KW - Autoantibodies

KW - CSF

KW - Galanin

KW - Neurodegeneration

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