TY - JOUR
T1 - Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors
AU - Veschi, V.
AU - Petroni, M.
AU - Bartolazzi, A.
AU - Altavista, P.
AU - Dominici, C.
AU - Capalbo, C.
AU - Boldrini, R.
AU - Castellano, A.
AU - McDowell, H. P.
AU - Pizer, B.
AU - Frati, L.
AU - Screpanti, I.
AU - Gulino, A.
AU - Giannini, G.
PY - 2014
Y1 - 2014
N2 - Childhood neuroblastic tumors are characterized by heterogeneous clinical courses, ranging from benign ganglioneuroma (GN) to highly lethal neuroblastoma (NB). Although a refined prognostic evaluation and risk stratification of each tumor patient is becoming increasingly essential to personalize treatment options, currently only few biomolecular markers (essentially MYCN amplification, chromosome 11q status and DNA ploidy) are validated for this purpose in neuroblastic tumors. Here we report that Galectin-3 (Gal-3), a β-galactoside-binding lectin involved in multiple biological functions that has already acquired diagnostic relevance in specific clinical settings, is variably expressed in most differentiated and less aggressive neuroblastic tumors, such as GN and ganglioneuroblastoma, as well as in a subset of NB cases. Gal-3 expression is associated with the INPC histopathological categorization (P
AB - Childhood neuroblastic tumors are characterized by heterogeneous clinical courses, ranging from benign ganglioneuroma (GN) to highly lethal neuroblastoma (NB). Although a refined prognostic evaluation and risk stratification of each tumor patient is becoming increasingly essential to personalize treatment options, currently only few biomolecular markers (essentially MYCN amplification, chromosome 11q status and DNA ploidy) are validated for this purpose in neuroblastic tumors. Here we report that Galectin-3 (Gal-3), a β-galactoside-binding lectin involved in multiple biological functions that has already acquired diagnostic relevance in specific clinical settings, is variably expressed in most differentiated and less aggressive neuroblastic tumors, such as GN and ganglioneuroblastoma, as well as in a subset of NB cases. Gal-3 expression is associated with the INPC histopathological categorization (P
KW - Neural cell differentiation
KW - Neuroblastoma
KW - Neuroblastoma prognostic factor
KW - Schwannian stroma
UR - http://www.scopus.com/inward/record.url?scp=84897462082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897462082&partnerID=8YFLogxK
U2 - 10.1038/cddis.2014.68
DO - 10.1038/cddis.2014.68
M3 - Article
C2 - 24603328
AN - SCOPUS:84897462082
VL - 5
JO - Cell Death and Disease
JF - Cell Death and Disease
SN - 2041-4889
IS - 3
M1 - e1100
ER -