Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors

V. Veschi, M. Petroni, A. Bartolazzi, P. Altavista, C. Dominici, C. Capalbo, R. Boldrini, A. Castellano, H. P. McDowell, B. Pizer, L. Frati, I. Screpanti, A. Gulino, G. Giannini

Research output: Contribution to journalArticlepeer-review

Abstract

Childhood neuroblastic tumors are characterized by heterogeneous clinical courses, ranging from benign ganglioneuroma (GN) to highly lethal neuroblastoma (NB). Although a refined prognostic evaluation and risk stratification of each tumor patient is becoming increasingly essential to personalize treatment options, currently only few biomolecular markers (essentially MYCN amplification, chromosome 11q status and DNA ploidy) are validated for this purpose in neuroblastic tumors. Here we report that Galectin-3 (Gal-3), a β-galactoside-binding lectin involved in multiple biological functions that has already acquired diagnostic relevance in specific clinical settings, is variably expressed in most differentiated and less aggressive neuroblastic tumors, such as GN and ganglioneuroblastoma, as well as in a subset of NB cases. Gal-3 expression is associated with the INPC histopathological categorization (P

Original languageEnglish
Article numbere1100
JournalCell Death and Disease
Volume5
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Neural cell differentiation
  • Neuroblastoma
  • Neuroblastoma prognostic factor
  • Schwannian stroma

ASJC Scopus subject areas

  • Cell Biology
  • Immunology
  • Cancer Research
  • Cellular and Molecular Neuroscience

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