Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4): European Journal of Cancer Prevention

V. Rosato, E. Negri, C. Bosetti, N. Malats, P. Gomez-Rubio, P. Consortium, P. Maisonneuve, A.B. Miller, H.B. Bueno-De-Mesquita, P.A. Baghurst, W. Zatonski, G.M. Petersen, G. Scelo, I. Holcatova, E. Fabianova, D. Serraino, S.H. Olson, J. Vioque, P. Lagiou, E.J. DuellP. Boffetta, C. La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Background The association among gallbladder disease, cholecystectomy, and pancreatic cancer is unclear. Moreover, time interval between gallbladder disease or cholecystectomy and pancreatic cancer diagnosis is not considered in most previous studies. Aim To quantify the association among gallbladder disease, cholecystectomy, and pancreatic cancer, considering time since first diagnosis of gallbladder disease or cholecystectomy. Methods We used data from nine case-control studies within the Pancreatic Cancer Case-Control Consortium, including 5760 cases of adenocarcinoma of the exocrine pancreas and 8437 controls. We estimated pooled odds ratios and the corresponding 95% confidence intervals by estimating study-specific odds ratios through multivariable unconditional logistic regression models, and then pooling the obtained estimates using fixed-effects models. Results Compared with patients with no history of gallbladder disease, the pooled odds ratio of pancreatic cancer was 1.69 (95% confidence interval, 1.51-1.88) for patients reporting a history of gallbladder disease. The odds ratio was 4.90 (95% confidence interval, 3.45-6.97) for gallbladder disease diagnosed
Original languageEnglish
Pages (from-to)408-415
Number of pages8
JournalEur.J. Cancer Prev.
Volume29
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • case-control studies
  • cholecystectomy
  • gallbladder disease
  • pancreatic cancer
  • pooled analysis
  • risk factors
  • adult
  • aged
  • Article
  • cancer diagnosis
  • cancer risk
  • case control study
  • comparative study
  • controlled study
  • disease association
  • exocrine pancreas
  • female
  • human
  • major clinical study
  • male
  • medical history
  • middle aged
  • pancreas adenocarcinoma
  • pancreas cancer
  • priority journal
  • sensitivity analysis

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