Gallbladder emptying in patients with primary achalasia

Eugenio Caturelli, Maria Maddalena Squillante, Saverio Fusilli, Antonio Aliotta, Caterina Cellerino, Alessandra Mangia, Luigino Gabbrielli

Research output: Contribution to journalArticlepeer-review


Being more evident that primary achalasia is not confined to the esophagus and that it may involve other organs in the digestive tract, gallbladder emptying was ultrasonographically evaluated in 10 patients affected with primary achalasia and in 10 controls. An intravenous cerulein infusion was used to induce gallbladder contraction. Eight out of 10 achalasic patients had a lower gallbladder emptying, and 6 out of 10 had a markedly delayed gallbladder emptying compared with the controls. Achalasic patients, taken as a whole, showed a significantly lower and delayed mean gallbladder emptying when compared with the controls. Such a finding confirms the possible extraesophageal extension of primary achalasia. In this study, the hypothesis of impaired cholinergic gallbladder innervation in primary achalasia is discussed.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
Issue number3-4
Publication statusPublished - 1992


  • Cerulein
  • Cholinergic fibers
  • Esophageal achalasia
  • Gallbladder
  • Ultrasonic diagnosis
  • Vagus nerve

ASJC Scopus subject areas

  • Gastroenterology


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