Gallstone disease and related risk factors in patients with Crohn disease: Analysis of 330 consecutive cases

M. Fraquelli, A. Losco, S. Visentin, B. M. Cesana, R. Pometta, A. Colli, D. Conte

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Background: The reported prevalence of gallstone disease (GD), defined as current gallstones or previous cholecystectomy for gallstones, in patients with Crohn disease ranges from 13% to 34%. The aim of this study was to characterize the still undefined risk factors of this complication. Methods: A total of 330 consecutive patients with Crohn disease (189 males and 141 females aged 17-82 years, mean±SD age, 41 ± 14 years) underwent liver ultrasonography. Results: A diagnosis of GD was made in 78 patients (24%), 54 with current gallstones and 24 who had undergone previous cholecystectomy. Its frequency was comparable in males and females (23% vs 25%), but was significantly associated with age (P=.001), being 13%, 36%, and 51% in patients aged 44 years and younger, 45 to 59 years, and 60 years and older, respectively (P=.001). Its prevalence significantly differed according to the site of the disease at diagnosis (P=.02) and was unrelated to disease duration. Gallstone disease was more frequent in patients who had undergone surgery (34% vs 14%; P=.001) and was significantly associated with the number (P=.001) and site of bowel resections (P=.001), increasing from 28% in the patients who had undergone 1 resection to 53% in those having had 2 or more resections (P=.005) and being significantly higher in patients with a resection involving the ileocecal region. Multivariate analysis showed that age; site of disease at diagnosis; and the presence, number, and site of bowel resections were significantly related to GD. Conclusions: In patients with Crohn disease, the frequency of GD is significantly higher than that reported in the general population with comparable characteristics (z=5.04, P

Original languageEnglish
Pages (from-to)2201-2204
Number of pages4
JournalArchives of Internal Medicine
Issue number18
Publication statusPublished - Oct 8 2001

ASJC Scopus subject areas

  • Internal Medicine


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