Abstract
Background: The reported prevalence of gallstone disease (GD), defined as current gallstones or previous cholecystectomy for gallstones, in patients with Crohn disease ranges from 13% to 34%. The aim of this study was to characterize the still undefined risk factors of this complication. Methods: A total of 330 consecutive patients with Crohn disease (189 males and 141 females aged 17-82 years, mean±SD age, 41 ± 14 years) underwent liver ultrasonography. Results: A diagnosis of GD was made in 78 patients (24%), 54 with current gallstones and 24 who had undergone previous cholecystectomy. Its frequency was comparable in males and females (23% vs 25%), but was significantly associated with age (P=.001), being 13%, 36%, and 51% in patients aged 44 years and younger, 45 to 59 years, and 60 years and older, respectively (P=.001). Its prevalence significantly differed according to the site of the disease at diagnosis (P=.02) and was unrelated to disease duration. Gallstone disease was more frequent in patients who had undergone surgery (34% vs 14%; P=.001) and was significantly associated with the number (P=.001) and site of bowel resections (P=.001), increasing from 28% in the patients who had undergone 1 resection to 53% in those having had 2 or more resections (P=.005) and being significantly higher in patients with a resection involving the ileocecal region. Multivariate analysis showed that age; site of disease at diagnosis; and the presence, number, and site of bowel resections were significantly related to GD. Conclusions: In patients with Crohn disease, the frequency of GD is significantly higher than that reported in the general population with comparable characteristics (z=5.04, P
| Original language | English |
|---|---|
| Pages (from-to) | 2201-2204 |
| Number of pages | 4 |
| Journal | Archives of Internal Medicine |
| Volume | 161 |
| Issue number | 18 |
| Publication status | Published - Oct 8 2001 |
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Gallstone disease and related risk factors in patients with Crohn disease : Analysis of 330 consecutive cases. / Fraquelli, M.; Losco, A.; Visentin, S.; Cesana, B. M.; Pometta, R.; Colli, A.; Conte, D.
In: Archives of Internal Medicine, Vol. 161, No. 18, 08.10.2001, p. 2201-2204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gallstone disease and related risk factors in patients with Crohn disease
T2 - Analysis of 330 consecutive cases
AU - Fraquelli, M.
AU - Losco, A.
AU - Visentin, S.
AU - Cesana, B. M.
AU - Pometta, R.
AU - Colli, A.
AU - Conte, D.
PY - 2001/10/8
Y1 - 2001/10/8
N2 - Background: The reported prevalence of gallstone disease (GD), defined as current gallstones or previous cholecystectomy for gallstones, in patients with Crohn disease ranges from 13% to 34%. The aim of this study was to characterize the still undefined risk factors of this complication. Methods: A total of 330 consecutive patients with Crohn disease (189 males and 141 females aged 17-82 years, mean±SD age, 41 ± 14 years) underwent liver ultrasonography. Results: A diagnosis of GD was made in 78 patients (24%), 54 with current gallstones and 24 who had undergone previous cholecystectomy. Its frequency was comparable in males and females (23% vs 25%), but was significantly associated with age (P=.001), being 13%, 36%, and 51% in patients aged 44 years and younger, 45 to 59 years, and 60 years and older, respectively (P=.001). Its prevalence significantly differed according to the site of the disease at diagnosis (P=.02) and was unrelated to disease duration. Gallstone disease was more frequent in patients who had undergone surgery (34% vs 14%; P=.001) and was significantly associated with the number (P=.001) and site of bowel resections (P=.001), increasing from 28% in the patients who had undergone 1 resection to 53% in those having had 2 or more resections (P=.005) and being significantly higher in patients with a resection involving the ileocecal region. Multivariate analysis showed that age; site of disease at diagnosis; and the presence, number, and site of bowel resections were significantly related to GD. Conclusions: In patients with Crohn disease, the frequency of GD is significantly higher than that reported in the general population with comparable characteristics (z=5.04, P
AB - Background: The reported prevalence of gallstone disease (GD), defined as current gallstones or previous cholecystectomy for gallstones, in patients with Crohn disease ranges from 13% to 34%. The aim of this study was to characterize the still undefined risk factors of this complication. Methods: A total of 330 consecutive patients with Crohn disease (189 males and 141 females aged 17-82 years, mean±SD age, 41 ± 14 years) underwent liver ultrasonography. Results: A diagnosis of GD was made in 78 patients (24%), 54 with current gallstones and 24 who had undergone previous cholecystectomy. Its frequency was comparable in males and females (23% vs 25%), but was significantly associated with age (P=.001), being 13%, 36%, and 51% in patients aged 44 years and younger, 45 to 59 years, and 60 years and older, respectively (P=.001). Its prevalence significantly differed according to the site of the disease at diagnosis (P=.02) and was unrelated to disease duration. Gallstone disease was more frequent in patients who had undergone surgery (34% vs 14%; P=.001) and was significantly associated with the number (P=.001) and site of bowel resections (P=.001), increasing from 28% in the patients who had undergone 1 resection to 53% in those having had 2 or more resections (P=.005) and being significantly higher in patients with a resection involving the ileocecal region. Multivariate analysis showed that age; site of disease at diagnosis; and the presence, number, and site of bowel resections were significantly related to GD. Conclusions: In patients with Crohn disease, the frequency of GD is significantly higher than that reported in the general population with comparable characteristics (z=5.04, P
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M3 - Article
C2 - 11575976
AN - SCOPUS:0035829047
VL - 161
SP - 2201
EP - 2204
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
SN - 0003-9926
IS - 18
ER -