Gallstones and biliary sludge in Greek patients with complete high spinal cord injury: An ultrasonographical evaluation

C. S. Baltas, A. P. Balanika, M. N. Sgantzos, O. Papakonstantinou, T. Spyridopoulos, V. Bizimi, M. Tsouroulas, Giuseppe Guglielmi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: We used ultrasonography to detect the presence of biliary sludge or gallstones in Greek patients with complete high spinal cord injury (SCI) above the seventh thoracic segment (T7), within the first six months from injury onset, in order to evaluate the effects of neurological instability and dysfunction of the sympathetic nervous system (SNS) on the gallbladder function in the early post-SCI phase. Methods: We evaluated 78 asymptomatic patients (57 males, 21 females; mean age 34.8 (range 19-56) years) with complete high SCI located above the T7 segment, and 78 healthy subjects (59 males, 19 females; mean age 35.2 (range 21-59) years) matched for age, gender and race, for a total period of 39 months. All the participants underwent ultrasonographical examination of the gallbladder and common bile duct within the first six months from the injury, in order to investigate the development of biliary sludge and gallstones. Results: The incidence of biliary sludge was significantly higher in patients with SCI compared with the control group. The incidence of biliary sludge and gallstones was also significantly higher in patients with SCI patients in comparison with the healthy subjects. In male SCI patients, the incidence of biliary sludge was significantly increased in comparison with healthy subjects. No significant difference was revealed between the two groups in detection of gallstones. Conclusion: Our study indicates that the detection of gallbladder sludge and gallstones are significantly higher in Greek patients with complete high SCI above the T7 segment, as compared with healthy control subjects within the first six months of the injury onset. The complete disruption of the SNS and the neurological instability in the early post-SCI phase is probably responsible for the biliary sludge and gallstone formation. Our results suggest that ultrasonography should be performed in these patients at the first 3-6 months from the injury for the early diagnosis of the lithogenic bile.

Original languageEnglish
Pages (from-to)889-893
Number of pages5
JournalSingapore Medical Journal
Volume50
Issue number9
Publication statusPublished - Sep 2009

Fingerprint

Gallstones
Spinal Cord Injuries
Bile
Healthy Volunteers
Gallbladder
Sympathetic Nervous System
Wounds and Injuries
Ultrasonography
Incidence
Common Bile Duct
Sewage
Early Diagnosis
Thorax
Control Groups

Keywords

  • Biliary sludge
  • Gallstones
  • Spinal cord injury
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Baltas, C. S., Balanika, A. P., Sgantzos, M. N., Papakonstantinou, O., Spyridopoulos, T., Bizimi, V., ... Guglielmi, G. (2009). Gallstones and biliary sludge in Greek patients with complete high spinal cord injury: An ultrasonographical evaluation. Singapore Medical Journal, 50(9), 889-893.

Gallstones and biliary sludge in Greek patients with complete high spinal cord injury : An ultrasonographical evaluation. / Baltas, C. S.; Balanika, A. P.; Sgantzos, M. N.; Papakonstantinou, O.; Spyridopoulos, T.; Bizimi, V.; Tsouroulas, M.; Guglielmi, Giuseppe.

In: Singapore Medical Journal, Vol. 50, No. 9, 09.2009, p. 889-893.

Research output: Contribution to journalArticle

Baltas, CS, Balanika, AP, Sgantzos, MN, Papakonstantinou, O, Spyridopoulos, T, Bizimi, V, Tsouroulas, M & Guglielmi, G 2009, 'Gallstones and biliary sludge in Greek patients with complete high spinal cord injury: An ultrasonographical evaluation', Singapore Medical Journal, vol. 50, no. 9, pp. 889-893.
Baltas CS, Balanika AP, Sgantzos MN, Papakonstantinou O, Spyridopoulos T, Bizimi V et al. Gallstones and biliary sludge in Greek patients with complete high spinal cord injury: An ultrasonographical evaluation. Singapore Medical Journal. 2009 Sep;50(9):889-893.
Baltas, C. S. ; Balanika, A. P. ; Sgantzos, M. N. ; Papakonstantinou, O. ; Spyridopoulos, T. ; Bizimi, V. ; Tsouroulas, M. ; Guglielmi, Giuseppe. / Gallstones and biliary sludge in Greek patients with complete high spinal cord injury : An ultrasonographical evaluation. In: Singapore Medical Journal. 2009 ; Vol. 50, No. 9. pp. 889-893.
@article{2f1bd6e58548443484a24a3b456f0b6d,
title = "Gallstones and biliary sludge in Greek patients with complete high spinal cord injury: An ultrasonographical evaluation",
abstract = "Introduction: We used ultrasonography to detect the presence of biliary sludge or gallstones in Greek patients with complete high spinal cord injury (SCI) above the seventh thoracic segment (T7), within the first six months from injury onset, in order to evaluate the effects of neurological instability and dysfunction of the sympathetic nervous system (SNS) on the gallbladder function in the early post-SCI phase. Methods: We evaluated 78 asymptomatic patients (57 males, 21 females; mean age 34.8 (range 19-56) years) with complete high SCI located above the T7 segment, and 78 healthy subjects (59 males, 19 females; mean age 35.2 (range 21-59) years) matched for age, gender and race, for a total period of 39 months. All the participants underwent ultrasonographical examination of the gallbladder and common bile duct within the first six months from the injury, in order to investigate the development of biliary sludge and gallstones. Results: The incidence of biliary sludge was significantly higher in patients with SCI compared with the control group. The incidence of biliary sludge and gallstones was also significantly higher in patients with SCI patients in comparison with the healthy subjects. In male SCI patients, the incidence of biliary sludge was significantly increased in comparison with healthy subjects. No significant difference was revealed between the two groups in detection of gallstones. Conclusion: Our study indicates that the detection of gallbladder sludge and gallstones are significantly higher in Greek patients with complete high SCI above the T7 segment, as compared with healthy control subjects within the first six months of the injury onset. The complete disruption of the SNS and the neurological instability in the early post-SCI phase is probably responsible for the biliary sludge and gallstone formation. Our results suggest that ultrasonography should be performed in these patients at the first 3-6 months from the injury for the early diagnosis of the lithogenic bile.",
keywords = "Biliary sludge, Gallstones, Spinal cord injury, Ultrasonography",
author = "Baltas, {C. S.} and Balanika, {A. P.} and Sgantzos, {M. N.} and O. Papakonstantinou and T. Spyridopoulos and V. Bizimi and M. Tsouroulas and Giuseppe Guglielmi",
year = "2009",
month = "9",
language = "English",
volume = "50",
pages = "889--893",
journal = "Singapore Medical Journal",
issn = "0037-5675",
publisher = "Singapore Medical Association",
number = "9",

}

TY - JOUR

T1 - Gallstones and biliary sludge in Greek patients with complete high spinal cord injury

T2 - An ultrasonographical evaluation

AU - Baltas, C. S.

AU - Balanika, A. P.

AU - Sgantzos, M. N.

AU - Papakonstantinou, O.

AU - Spyridopoulos, T.

AU - Bizimi, V.

AU - Tsouroulas, M.

AU - Guglielmi, Giuseppe

PY - 2009/9

Y1 - 2009/9

N2 - Introduction: We used ultrasonography to detect the presence of biliary sludge or gallstones in Greek patients with complete high spinal cord injury (SCI) above the seventh thoracic segment (T7), within the first six months from injury onset, in order to evaluate the effects of neurological instability and dysfunction of the sympathetic nervous system (SNS) on the gallbladder function in the early post-SCI phase. Methods: We evaluated 78 asymptomatic patients (57 males, 21 females; mean age 34.8 (range 19-56) years) with complete high SCI located above the T7 segment, and 78 healthy subjects (59 males, 19 females; mean age 35.2 (range 21-59) years) matched for age, gender and race, for a total period of 39 months. All the participants underwent ultrasonographical examination of the gallbladder and common bile duct within the first six months from the injury, in order to investigate the development of biliary sludge and gallstones. Results: The incidence of biliary sludge was significantly higher in patients with SCI compared with the control group. The incidence of biliary sludge and gallstones was also significantly higher in patients with SCI patients in comparison with the healthy subjects. In male SCI patients, the incidence of biliary sludge was significantly increased in comparison with healthy subjects. No significant difference was revealed between the two groups in detection of gallstones. Conclusion: Our study indicates that the detection of gallbladder sludge and gallstones are significantly higher in Greek patients with complete high SCI above the T7 segment, as compared with healthy control subjects within the first six months of the injury onset. The complete disruption of the SNS and the neurological instability in the early post-SCI phase is probably responsible for the biliary sludge and gallstone formation. Our results suggest that ultrasonography should be performed in these patients at the first 3-6 months from the injury for the early diagnosis of the lithogenic bile.

AB - Introduction: We used ultrasonography to detect the presence of biliary sludge or gallstones in Greek patients with complete high spinal cord injury (SCI) above the seventh thoracic segment (T7), within the first six months from injury onset, in order to evaluate the effects of neurological instability and dysfunction of the sympathetic nervous system (SNS) on the gallbladder function in the early post-SCI phase. Methods: We evaluated 78 asymptomatic patients (57 males, 21 females; mean age 34.8 (range 19-56) years) with complete high SCI located above the T7 segment, and 78 healthy subjects (59 males, 19 females; mean age 35.2 (range 21-59) years) matched for age, gender and race, for a total period of 39 months. All the participants underwent ultrasonographical examination of the gallbladder and common bile duct within the first six months from the injury, in order to investigate the development of biliary sludge and gallstones. Results: The incidence of biliary sludge was significantly higher in patients with SCI compared with the control group. The incidence of biliary sludge and gallstones was also significantly higher in patients with SCI patients in comparison with the healthy subjects. In male SCI patients, the incidence of biliary sludge was significantly increased in comparison with healthy subjects. No significant difference was revealed between the two groups in detection of gallstones. Conclusion: Our study indicates that the detection of gallbladder sludge and gallstones are significantly higher in Greek patients with complete high SCI above the T7 segment, as compared with healthy control subjects within the first six months of the injury onset. The complete disruption of the SNS and the neurological instability in the early post-SCI phase is probably responsible for the biliary sludge and gallstone formation. Our results suggest that ultrasonography should be performed in these patients at the first 3-6 months from the injury for the early diagnosis of the lithogenic bile.

KW - Biliary sludge

KW - Gallstones

KW - Spinal cord injury

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=70350509557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350509557&partnerID=8YFLogxK

M3 - Article

C2 - 19787178

AN - SCOPUS:70350509557

VL - 50

SP - 889

EP - 893

JO - Singapore Medical Journal

JF - Singapore Medical Journal

SN - 0037-5675

IS - 9

ER -