GALNT2 effect on HDL-cholesterol and triglycerides levels in humans: Evidence of pleiotropy?

Research output: Contribution to journalShort surveypeer-review

Abstract

A wide range of studies both in humans and animal models point GALNT2 as a shaper of serum HDL-C and TG levels. Available data in humans indicate that, while under conditions of extreme GALNT2 loss-of-function HDL-C is the main target, a fine-tuning of GALNT2 changes is mostly associated with TG levels. Understanding whether different degrees of GALNT2 change do modulate different serum lipid fractions and, if so, addressing the mechanisms underlying such pleiotropic effects has the potential not only to improve our understanding of HDL-C and TG metabolism, but also to make GALNT2 becoming a target for treating atherogenic dyslipidemia and related clinical events.

Original languageEnglish
Pages (from-to)281-282
Number of pages2
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume27
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Expression levels
  • GALNT2
  • Lipid levels

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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