GALNT2 Expression Is Reduced in Patients with Type 2 Diabetes

Possible Role of Hyperglycemia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Impaired insulin action plays a major role in the pathogenesis of type 2 diabetes, a chronic metabolic disorder which imposes a tremendous burden to morbidity and mortality worldwide. Unraveling the molecular mechanisms underlying insulin resistance would improve setting up preventive and treatment strategies of type 2 diabetes. Down-regulation of GALNT2, an UDPN-acetyl-alpha-D-galactosamine polypeptideN-acetylgalactosaminyltransferase-2 (ppGalNAc-T2), causes impaired insulin signaling and action in cultured human liver cells. In addition, GALNT2 mRNA levels are down-regulated in liver of spontaneously insulin resistant, diabetic Goto-Kakizaki rats. To investigate the role of GALNT2 in human hyperglycemia, we measured GALNT2 mRNA expression levels in peripheral whole blood cells of 84 non-obese and 46 obese non-diabetic individuals as well as of 98 obese patients with type 2 diabetes. We also measured GALNT2 mRNA expression in human U937 cells cultured under different glucose concentrations. In vivo studies indicated that GALNT2 mRNA levels were significantly reduced from non obese control to obese non diabetic and to obese diabetic individuals (p

Original languageEnglish
Article numbere70159
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 22 2013

Fingerprint

hyperglycemia
Medical problems
noninsulin-dependent diabetes mellitus
Hyperglycemia
Type 2 Diabetes Mellitus
Insulin
insulin resistance
Messenger RNA
insulin
Liver
galactosamine
metabolic diseases
blood cells
in vivo studies
Galactosamine
cultured cells
U937 Cells
hepatocytes
morbidity
pathogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

GALNT2 Expression Is Reduced in Patients with Type 2 Diabetes : Possible Role of Hyperglycemia. / Marucci, Antonella; di Mauro, Lazzaro; Menzaghi, Claudia; Prudente, Sabrina; Mangiacotti, Davide; Fini, Grazia; Lotti, Giuseppe; Trischitta, Vincenzo; Di Paola, Rosa.

In: PLoS One, Vol. 8, No. 7, e70159, 22.07.2013.

Research output: Contribution to journalArticle

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