Gamma-delta T-cell lymphomas

Claudio Tripodo, Emilio Iannitto, Ada Maria Florena, Carlo Ennio Pucillo, Pier Paolo Piccaluga, Vito Franco, Stefano Aldo Pileri

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which γδ T-cell receptors are expressed (γδ TCLs) are extremely aggressive and rare (≤1% of lymphoid neoplasms). γδ TCLs originate from γδ T cells, a small subset of peripheral T cells with direct antigen recognition capability acting at the interface between innate and adaptive immunity. Two distinct γδ TCL entities are recognized: hepatosplenic T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). HSTL is a well-characterized extranodal lymphoma that has a disguised onset, secondary to intrasinusoidal infiltration of the spleen, liver and bone marrow, has a rapidly progressive course that is poorly responsive to chemotherapy, and often ensues in the setting of immune system suppression. PCGD-TCL can present with prominent epidermal involvement or with a panniculitis-like clinical picture that can be complicated by a concurrent hemophagocytic syndrome; the disease shows biological and phenotypic overlap with other extranodal γδ TCLs that involve the respiratory or gastrointestinal tract mucosa. The regular application of phenotypic and molecular techniques is crucial for the diagnosis of γδ TCLs. In this Review, we discuss the clinical and biological features, the diagnostic challenges and the therapeutic perspectives of HSTL and PCGD-TCL.

Original languageEnglish
Pages (from-to)707-717
Number of pages11
JournalNature Reviews Clinical Oncology
Volume6
Issue number12
DOIs
Publication statusPublished - 2009

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Somatostatin-Secreting Cells
T-Cell Lymphoma
Peripheral T-Cell Lymphoma
Panniculitis
Hemophagocytic Lymphohistiocytosis
Cutaneous T-Cell Lymphoma
Neoplasms
T-Lymphocyte Subsets
Adaptive Immunity
T-Cell Antigen Receptor
Innate Immunity
Respiratory System
Gastrointestinal Tract
Immune System
Lymphoma
Mucous Membrane
Spleen
Bone Marrow

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

Cite this

Tripodo, C., Iannitto, E., Florena, A. M., Pucillo, C. E., Piccaluga, P. P., Franco, V., & Pileri, S. A. (2009). Gamma-delta T-cell lymphomas. Nature Reviews Clinical Oncology, 6(12), 707-717. https://doi.org/10.1038/nrclinonc.2009.169

Gamma-delta T-cell lymphomas. / Tripodo, Claudio; Iannitto, Emilio; Florena, Ada Maria; Pucillo, Carlo Ennio; Piccaluga, Pier Paolo; Franco, Vito; Pileri, Stefano Aldo.

In: Nature Reviews Clinical Oncology, Vol. 6, No. 12, 2009, p. 707-717.

Research output: Contribution to journalArticle

Tripodo, C, Iannitto, E, Florena, AM, Pucillo, CE, Piccaluga, PP, Franco, V & Pileri, SA 2009, 'Gamma-delta T-cell lymphomas', Nature Reviews Clinical Oncology, vol. 6, no. 12, pp. 707-717. https://doi.org/10.1038/nrclinonc.2009.169
Tripodo C, Iannitto E, Florena AM, Pucillo CE, Piccaluga PP, Franco V et al. Gamma-delta T-cell lymphomas. Nature Reviews Clinical Oncology. 2009;6(12):707-717. https://doi.org/10.1038/nrclinonc.2009.169
Tripodo, Claudio ; Iannitto, Emilio ; Florena, Ada Maria ; Pucillo, Carlo Ennio ; Piccaluga, Pier Paolo ; Franco, Vito ; Pileri, Stefano Aldo. / Gamma-delta T-cell lymphomas. In: Nature Reviews Clinical Oncology. 2009 ; Vol. 6, No. 12. pp. 707-717.
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