Gamma-glutamyltranspeptidase (GGTP)

Its relationship to other parameters for diagnosis of alcoholic liver disease

G. C. Actis, A. Ponzetto, A. Andriulli, L. Gubetta, G. Verme

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To determine the value of serum GGTP determination in the diagnosis of alcohol-related liver injury, 14 alcoholics with various degrees of biopsy-prove liver damage and 16 subject suffering from non-alcoholic liver disease were studied. GGTP was increased in 100% of the alcoholics and in 75% of the non-alcoholic patients. The mean value of this enzyme differed significantly between the two groups (P <0.02). No relationship could be established between GGTP values and the degree of liver damage as seen by needle biopsy.In addition, GGTP was studied in comparison with alkaline phosphatase (GGTP/AP ratio). This index proved even more useful in discriminating the two groups (P <0.005). GGTP can be considered a good diagnositc tool for alcoholic liver disease, especially when combined with a test of cholestasis. However, the high sensitivity of GGTP to non-specific factors such as enzyme-inducing drugs, may prove misleading and should be kept in mind in the differential diagnosis of liver disease.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalPathologica
Volume71
Issue number1011
Publication statusPublished - 1979

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Alcoholic Liver Diseases
Alcoholics
Liver Diseases
Liver
Cholestasis
Needle Biopsy
Enzymes
Alkaline Phosphatase
Differential Diagnosis
Alcohols
Biopsy
Wounds and Injuries
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Gamma-glutamyltranspeptidase (GGTP) : Its relationship to other parameters for diagnosis of alcoholic liver disease. / Actis, G. C.; Ponzetto, A.; Andriulli, A.; Gubetta, L.; Verme, G.

In: Pathologica, Vol. 71, No. 1011, 1979, p. 73-80.

Research output: Contribution to journalArticle

Actis, G. C. ; Ponzetto, A. ; Andriulli, A. ; Gubetta, L. ; Verme, G. / Gamma-glutamyltranspeptidase (GGTP) : Its relationship to other parameters for diagnosis of alcoholic liver disease. In: Pathologica. 1979 ; Vol. 71, No. 1011. pp. 73-80.
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