Abstract
This report describes the clinical, pathologic, and immunologic features of a patient with γ heavy chain disease (γ-HCD) associated with Hodgkin's disease (HD). The diagnosis of γ-HCD was established by serum electrophoresis and immunoelectrophoresis and confirmed by biochemical analysis of patient's serum showing the presence of an incomplete γ chain, with an approximate molecular weight of 40 kilodaltons. The diagnosis of HD rested upon the presence of systemic lymphadenopathy, the typical histologic pattern and reactivity of Reed-Sternberg cells with the LeuM1-CD15 monoclonal antibody. The two diseases developed independently, in the absence of any immunosuppressive treatment. Furthermore, there was some evidence suggesting that HD tissue was not responsible for the production of the incomplete γ chain. This and similar cases may provide a model for a better understanding of the events leading to the simultaneous outgrowth of two lymphoid neoplasias in the same patient.
| Original language | English |
|---|---|
| Pages (from-to) | 1804-1809 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 63 |
| Issue number | 9 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Gamma heavy chain disease associated with Hodgkin's disease. Clinical, pathologic, and immunologic features of one case. / Di Benedetto, G.; Cataldi, A.; Verde, A.; Gloghini, A.; Nicolo, G.; Pistoia, V.
In: Cancer, Vol. 63, No. 9, 1989, p. 1804-1809.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Gamma heavy chain disease associated with Hodgkin's disease. Clinical, pathologic, and immunologic features of one case
AU - Di Benedetto, G.
AU - Cataldi, A.
AU - Verde, A.
AU - Gloghini, A.
AU - Nicolo, G.
AU - Pistoia, V.
PY - 1989
Y1 - 1989
N2 - This report describes the clinical, pathologic, and immunologic features of a patient with γ heavy chain disease (γ-HCD) associated with Hodgkin's disease (HD). The diagnosis of γ-HCD was established by serum electrophoresis and immunoelectrophoresis and confirmed by biochemical analysis of patient's serum showing the presence of an incomplete γ chain, with an approximate molecular weight of 40 kilodaltons. The diagnosis of HD rested upon the presence of systemic lymphadenopathy, the typical histologic pattern and reactivity of Reed-Sternberg cells with the LeuM1-CD15 monoclonal antibody. The two diseases developed independently, in the absence of any immunosuppressive treatment. Furthermore, there was some evidence suggesting that HD tissue was not responsible for the production of the incomplete γ chain. This and similar cases may provide a model for a better understanding of the events leading to the simultaneous outgrowth of two lymphoid neoplasias in the same patient.
AB - This report describes the clinical, pathologic, and immunologic features of a patient with γ heavy chain disease (γ-HCD) associated with Hodgkin's disease (HD). The diagnosis of γ-HCD was established by serum electrophoresis and immunoelectrophoresis and confirmed by biochemical analysis of patient's serum showing the presence of an incomplete γ chain, with an approximate molecular weight of 40 kilodaltons. The diagnosis of HD rested upon the presence of systemic lymphadenopathy, the typical histologic pattern and reactivity of Reed-Sternberg cells with the LeuM1-CD15 monoclonal antibody. The two diseases developed independently, in the absence of any immunosuppressive treatment. Furthermore, there was some evidence suggesting that HD tissue was not responsible for the production of the incomplete γ chain. This and similar cases may provide a model for a better understanding of the events leading to the simultaneous outgrowth of two lymphoid neoplasias in the same patient.
UR - http://www.scopus.com/inward/record.url?scp=0024514713&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024514713&partnerID=8YFLogxK
M3 - Article
VL - 63
SP - 1804
EP - 1809
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 9
ER -