GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME

L. Gallimberti, N. Gentile, M. Cibin, F. Fadda, G. Canton, M. Ferri, S. D. Ferrara, G. L. Gessa

Research output: Contribution to journalArticle

Abstract

The effect of gamma-hydroxybutyric acid (GHB) on ethanol withdrawal syndrome in alcoholics was investigated in a randomised double-blind study. Patients with withdrawal symptoms were treated either with GHB (orally in a syrup preparation) (11 patients) or with the syrup alone (12). GHB treatment (50 mg/kg) led to a prompt reduction in withdrawal symptoms, such as tremors, sweating, nausea, depression, anxiety, and restlessness. The only side-effect was dizziness. GHB may be useful in the management of alcohol withdrawal syndrome in man.

Original languageEnglish
Pages (from-to)787-789
Number of pages3
JournalLancet
Volume334
Issue number8666
DOIs
Publication statusPublished - Sep 30 1989

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Gallimberti, L., Gentile, N., Cibin, M., Fadda, F., Canton, G., Ferri, M., Ferrara, S. D., & Gessa, G. L. (1989). GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME. Lancet, 334(8666), 787-789. https://doi.org/10.1016/S0140-6736(89)90842-8