GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME

L. Gallimberti, N. Gentile, M. Cibin, F. Fadda, G. Canton, M. Ferri, S. D. Ferrara, G. L. Gessa

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

The effect of gamma-hydroxybutyric acid (GHB) on ethanol withdrawal syndrome in alcoholics was investigated in a randomised double-blind study. Patients with withdrawal symptoms were treated either with GHB (orally in a syrup preparation) (11 patients) or with the syrup alone (12). GHB treatment (50 mg/kg) led to a prompt reduction in withdrawal symptoms, such as tremors, sweating, nausea, depression, anxiety, and restlessness. The only side-effect was dizziness. GHB may be useful in the management of alcohol withdrawal syndrome in man.

Original languageEnglish
Pages (from-to)787-789
Number of pages3
JournalLancet
Volume334
Issue number8666
DOIs
Publication statusPublished - Sep 30 1989

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Alcohols
Substance Withdrawal Syndrome
Psychomotor Agitation
Sweating
Dizziness
Tremor
Therapeutics
Alcoholics
Double-Blind Method
Nausea
Ethanol
Anxiety
Depression
4-hydroxybutyric acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gallimberti, L., Gentile, N., Cibin, M., Fadda, F., Canton, G., Ferri, M., ... Gessa, G. L. (1989). GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME. Lancet, 334(8666), 787-789. https://doi.org/10.1016/S0140-6736(89)90842-8

GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME. / Gallimberti, L.; Gentile, N.; Cibin, M.; Fadda, F.; Canton, G.; Ferri, M.; Ferrara, S. D.; Gessa, G. L.

In: Lancet, Vol. 334, No. 8666, 30.09.1989, p. 787-789.

Research output: Contribution to journalArticle

Gallimberti, L, Gentile, N, Cibin, M, Fadda, F, Canton, G, Ferri, M, Ferrara, SD & Gessa, GL 1989, 'GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME', Lancet, vol. 334, no. 8666, pp. 787-789. https://doi.org/10.1016/S0140-6736(89)90842-8
Gallimberti L, Gentile N, Cibin M, Fadda F, Canton G, Ferri M et al. GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME. Lancet. 1989 Sep 30;334(8666):787-789. https://doi.org/10.1016/S0140-6736(89)90842-8
Gallimberti, L. ; Gentile, N. ; Cibin, M. ; Fadda, F. ; Canton, G. ; Ferri, M. ; Ferrara, S. D. ; Gessa, G. L. / GAMMA-HYDROXYBUTYRIC ACID FOR TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME. In: Lancet. 1989 ; Vol. 334, No. 8666. pp. 787-789.
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