Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double-blind study

L. Gallimberti, M. Ferri, S. D. Ferrara, F. Fadda, G. L. Gessa

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

The effect of gamma-hydroxybutyric acid on alcohol consumption and alcohol craving in alcoholics was investigated in a randomized double-blind study versus placebo. Patients were treated as outpatients during a three month period either with gamma-hydroxybutyric acid (50 mg/kg/day, divided into three daily doses) or with placebo. Of the 82 alcoholics that entered the study, 71 completed it, 36 in the gamma-hydroxybutyric acid and 35 in the placebo group. Alcohol consumption was assessed by the subject's self report. At the 3rd month of treatment, 11 patients in the gamma-hydroxybutyric acid group referred to be abstinent and 15 referred controlled drinking; while in the placebo group only two and six patients referred abstinence and controlled drinking, respectively. Serum-gammaglutamyl-transferase activity correlated with the admitted alcohol consumption. Gamma-hydroxybutyric acid treatment decreased alcohol craving during the 3 months of treatment. Transient side effects were noted by six patients on gamma-hydroxybutyric acid and two on placebo. The results suggest that gamma-hydroxybutyric acid may be useful in the treatment of alcohol dependence.

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number4
Publication statusPublished - 1992

Fingerprint

Double-Blind Method
Alcoholism
Alcohols
Placebos
Alcohol Drinking
Alcoholics
Therapeutics
Drinking
Transferases
4-hydroxybutyric acid
Self Report
Outpatients
Serum

Keywords

  • Alcohol Dependence
  • Craving
  • GHB

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Gallimberti, L., Ferri, M., Ferrara, S. D., Fadda, F., & Gessa, G. L. (1992). Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double-blind study. Alcoholism: Clinical and Experimental Research, 16(4), 673-676.

Gamma-hydroxybutyric acid in the treatment of alcohol dependence : A double-blind study. / Gallimberti, L.; Ferri, M.; Ferrara, S. D.; Fadda, F.; Gessa, G. L.

In: Alcoholism: Clinical and Experimental Research, Vol. 16, No. 4, 1992, p. 673-676.

Research output: Contribution to journalArticle

Gallimberti, L, Ferri, M, Ferrara, SD, Fadda, F & Gessa, GL 1992, 'Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double-blind study', Alcoholism: Clinical and Experimental Research, vol. 16, no. 4, pp. 673-676.
Gallimberti, L. ; Ferri, M. ; Ferrara, S. D. ; Fadda, F. ; Gessa, G. L. / Gamma-hydroxybutyric acid in the treatment of alcohol dependence : A double-blind study. In: Alcoholism: Clinical and Experimental Research. 1992 ; Vol. 16, No. 4. pp. 673-676.
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