Gamma-immunoglobulins and adeno-splenomegaly in chronic lymphocytic leukemia (CLL)

W. Paolino, V. Infelise, A. Levis, M. Falda, F. Locatelli, A. Jayme, M. Remondino

Research output: Contribution to journalArticlepeer-review


Out of 346 CLL cases followed from diagnosis, 86 had associated chronic diseases and consequently higher gamma- (p = 0.0004) and IgA (p = 0.0185) values; therefore they were not considered in this study. In the remaining 260 uncomplicated cases a tendency towards reduced globulin values at diagnosis was diffusely present. The Ig most frequently reduced was IgM (40%), followed by IgA and IgG. Considering lymph node and spleen involvement (graded 0 to +++), the group with the greatest leukemic expansion had the highest frequency of reduction in gammaglobulin, individual Ig's and all 3 Ig's taken together. In the same group, IgA had the lowest average value (p

Original languageEnglish
Pages (from-to)19-24
Number of pages6
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology


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