Gamma-interferon and retinoic acid induce human neuroblastoma cell differentiation following different biochemical pathways

M. Ponzoni, M. Lanciotti, [No Value] Cornaglia, P. Ferraris

Research output: Contribution to journalArticle

Abstract

We are here reporting evidence that Retinoic Acid (RA) and gamma-Interferon (γ-IFN) differently induce in vitro differentiation of LAN-1 cell line. Differences can be noted in morphological, phenotypic and biochemical mechanisms associated with the cellular differentiation process. We specifically show that RA induces a significant decrease of second messengers derived from phosphatidylinositol (PI) turnover, while the cellular differentiation induced by γ-IFN is not associated with modifications in the PI-derived metabolites. Based on these findings it is postulated here that appropriate combinations of differentiation inducing agents may possibly help in projecting newer experimental treatments which differ from the present clinical belief that maximal therapeutic response can only be reached after maximal toxicity.

Original languageEnglish
Pages (from-to)309-320
Number of pages12
JournalClinical Chemistry and Enzymology Communications
Volume2
Issue number4-6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Biochemistry

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