We are here reporting evidence that Retinoic Acid (RA) and gamma-Interferon (γ-IFN) differently induce in vitro differentiation of LAN-1 cell line. Differences can be noted in morphological, phenotypic and biochemical mechanisms associated with the cellular differentiation process. We specifically show that RA induces a significant decrease of second messengers derived from phosphatidylinositol (PI) turnover, while the cellular differentiation induced by γ-IFN is not associated with modifications in the PI-derived metabolites. Based on these findings it is postulated here that appropriate combinations of differentiation inducing agents may possibly help in projecting newer experimental treatments which differ from the present clinical belief that maximal therapeutic response can only be reached after maximal toxicity.
|Number of pages||12|
|Journal||Clinical Chemistry and Enzymology Communications|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Biochemistry