Gamma radiation-induced differentiation on human neuroblastoma cells in culture

P. Rocchi, A. M. Ferreri, G. Simone, D. Granchi, P. Nanni, A. Frau, P. Paolucci, G. Paolucci

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the effect of gamma radiation on differentiation in neuroblastoma cell lines AF8 and SJ-N-KP. Growth inhibition and morphological and biochemical differentiation have been examined following radiation exposure to 1-10 Gy. Gamma radiation induced marked growth inhibition and morphological differentiation in a dose-and time-dependent manner in both cell lines, and induced biochemical differentiation in AF8 cells.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalAnticancer Research
Volume13
Issue number2
Publication statusPublished - 1993

Keywords

  • γ-radiation
  • Differentiation
  • Neuroblastoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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