Cytomegalovirus (CMV) infection is a frequent complication in immunocompromised host and its clinical manifestation can be various, also very important, mainly in patients with allogenic bone marrow transplantation. In the case of maternal transmission of CMV infection the clinical expression can be a severe neurological syndrome or unapparent form with later neurological signs. Our 15 patients (10 allogenic bone marrow transplantation, 3 kidney transplantation, 1 treated with chemotherapy for acute myeloblastic leukemia and 1 for maternal CMV first-infection during pregnancy) received one or more courses of therapy with ganciclovir (total 21 treatment courses). In 14 episodes CMV infection was clearly documented and a therapeutic success, defined as lack or regression of clinical signs and survival of patient, was observed in 11 episodes (78%). Ganciclovir toxicity, in particular on bone marrow, kidney and liver, was evaluated in all 21 treatment courses: 9/21 (23%) treatment courses presented drug-related abnormalities. Bone marrow toxicity was prominent in bone marrow transplant recipients, requiring reduction of the administered dose in 6 patients. Renal and hepatic toxicity were moderate and less frequent. Nevertheless the observed toxicity, wer considered therapy with ganciclovir important in those patients in which documented CMV infection can be complicated with more serious manifestions, like CMV pneumonia. Further study is needed to evaluate ganciclovir efficacy in CMV infection with vertical transmission.
|Translated title of the contribution||Ganciclovir for treatment of Cytomegalovirus infection in pediatrics|
|Number of pages||5|
|Journal||Giornale di Malattie Infettive e Parassitarie|
|Publication status||Published - 1993|
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