Abstract
An 8-year-old male castrated cat was referred for sudden onset of lameness. Physical examination revealed a 1 × 2 × 1 cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 291-293 |
| Number of pages | 3 |
| Journal | Veterinary Journal |
| Volume | 178 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 2008 |
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Keywords
- Biphasic pulse
- Bleomycin
- Cisplatin
- Electrochemotherapy
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Ganglioneuroblastoma in a cat : A rare neoplasm treated with electrochemotherapy. / Spugnini, Enrico P.; Citro, Gennaro; Dotsinsky, Ivan; Mudrov, Nikolay; Mellone, Pasquale; Baldi, Alfonso.
In: Veterinary Journal, Vol. 178, No. 2, 11.2008, p. 291-293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ganglioneuroblastoma in a cat
T2 - A rare neoplasm treated with electrochemotherapy
AU - Spugnini, Enrico P.
AU - Citro, Gennaro
AU - Dotsinsky, Ivan
AU - Mudrov, Nikolay
AU - Mellone, Pasquale
AU - Baldi, Alfonso
PY - 2008/11
Y1 - 2008/11
N2 - An 8-year-old male castrated cat was referred for sudden onset of lameness. Physical examination revealed a 1 × 2 × 1 cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.
AB - An 8-year-old male castrated cat was referred for sudden onset of lameness. Physical examination revealed a 1 × 2 × 1 cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.
KW - Biphasic pulse
KW - Bleomycin
KW - Cisplatin
KW - Electrochemotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=47849094535&partnerID=8YFLogxK
U2 - 10.1016/j.tvjl.2007.08.014
DO - 10.1016/j.tvjl.2007.08.014
M3 - Article
C2 - 17910926
AN - SCOPUS:47849094535
VL - 178
SP - 291
EP - 293
JO - Veterinary Journal
JF - Veterinary Journal
SN - 1090-0233
IS - 2
ER -