Ganglioneuroblastoma in a cat: A rare neoplasm treated with electrochemotherapy

Enrico P. Spugnini, Gennaro Citro, Ivan Dotsinsky, Nikolay Mudrov, Pasquale Mellone, Alfonso Baldi

Research output: Contribution to journalArticle

Abstract

An 8-year-old male castrated cat was referred for sudden onset of lameness. Physical examination revealed a 1 × 2 × 1 cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.

Original languageEnglish
Pages (from-to)291-293
Number of pages3
JournalVeterinary Journal
Volume178
Issue number2
DOIs
Publication statusPublished - Nov 2008

Fingerprint

Electrochemotherapy
Ganglioneuroblastoma
Cats
cats
neoplasms
remission
Hematoxylin
Neoplasms
Staining and Labeling
phosphopyruvate hydratase
cisplatin
Intermediate Filaments
Phosphopyruvate Hydratase
vimentin
Glial Fibrillary Acidic Protein
Bleomycin
neuroglia
Vimentin
Eosine Yellowish-(YS)
lameness

Keywords

  • Biphasic pulse
  • Bleomycin
  • Cisplatin
  • Electrochemotherapy

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Spugnini, E. P., Citro, G., Dotsinsky, I., Mudrov, N., Mellone, P., & Baldi, A. (2008). Ganglioneuroblastoma in a cat: A rare neoplasm treated with electrochemotherapy. Veterinary Journal, 178(2), 291-293. https://doi.org/10.1016/j.tvjl.2007.08.014

Ganglioneuroblastoma in a cat : A rare neoplasm treated with electrochemotherapy. / Spugnini, Enrico P.; Citro, Gennaro; Dotsinsky, Ivan; Mudrov, Nikolay; Mellone, Pasquale; Baldi, Alfonso.

In: Veterinary Journal, Vol. 178, No. 2, 11.2008, p. 291-293.

Research output: Contribution to journalArticle

Spugnini, EP, Citro, G, Dotsinsky, I, Mudrov, N, Mellone, P & Baldi, A 2008, 'Ganglioneuroblastoma in a cat: A rare neoplasm treated with electrochemotherapy', Veterinary Journal, vol. 178, no. 2, pp. 291-293. https://doi.org/10.1016/j.tvjl.2007.08.014
Spugnini EP, Citro G, Dotsinsky I, Mudrov N, Mellone P, Baldi A. Ganglioneuroblastoma in a cat: A rare neoplasm treated with electrochemotherapy. Veterinary Journal. 2008 Nov;178(2):291-293. https://doi.org/10.1016/j.tvjl.2007.08.014
Spugnini, Enrico P. ; Citro, Gennaro ; Dotsinsky, Ivan ; Mudrov, Nikolay ; Mellone, Pasquale ; Baldi, Alfonso. / Ganglioneuroblastoma in a cat : A rare neoplasm treated with electrochemotherapy. In: Veterinary Journal. 2008 ; Vol. 178, No. 2. pp. 291-293.
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