Ganglioneuroblastoma in a cat: A rare neoplasm treated with electrochemotherapy

Enrico P. Spugnini, Gennaro Citro, Ivan Dotsinsky, Nikolay Mudrov, Pasquale Mellone, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review


An 8-year-old male castrated cat was referred for sudden onset of lameness. Physical examination revealed a 1 × 2 × 1 cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.

Original languageEnglish
Pages (from-to)291-293
Number of pages3
JournalVeterinary Journal
Issue number2
Publication statusPublished - Nov 2008


  • Biphasic pulse
  • Bleomycin
  • Cisplatin
  • Electrochemotherapy

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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