Ganglioneurocytoma of the spinal cord: Report of a case and review of literature

Gianluca Marucci, Andrea Barbanera, Elena Serchi, Alvaro Andreoli

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A case of ganglioneurocytoma of the spinal cord in a 51-year-old man is reported. Patient presented with a progressively worsening back pain and hyposthenia of lower limbs. Magnetic resonance imaging of the spinal cord revealed an intradural lesion in the T10-11 spinal segments, hyperintense on T1-weighted sequences. Complete resection was achieved. The patient did not show evidence of recurrence 12 months after surgery. On histology, the lesion was composed of round to oval cells with fine granular, slightly eosinophilic to clear cytoplasm suggesting a neurocytic differentiation. Some ganglion cells were observed. Neither significant cytologic atypia nor mitoses were present. The neoplastic cells were strongly positive with synaptophysin and negative with glial fibrillary acid protein. Neurocytomas are uncommon tumors typically arising within the lateral ventricles near the foramen of Monro. Extraventricular neurocytomas have been reported at various sites with rare examples in spinal cord. In the present paper, a case of ganglioneurocytoma of the spinal cord is reported with review of literature and discussion of differences compared to neurocytomas of other sites.

Original languageEnglish
JournalEuropean Spine Journal
Volume18
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Neurocytoma
Spinal Cord
Cerebral Ventricles
Synaptophysin
Lateral Ventricles
Glial Fibrillary Acidic Protein
Back Pain
Mitosis
Ganglia
Lower Extremity
Histology
Cytoplasm
Magnetic Resonance Imaging
Recurrence
Neoplasms

Keywords

  • Extraventricular neurocytoma
  • Ganglioneurocytoma
  • Neurocytic differentiation
  • Neurocytoma
  • Spinal cord

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Ganglioneurocytoma of the spinal cord : Report of a case and review of literature. / Marucci, Gianluca; Barbanera, Andrea; Serchi, Elena; Andreoli, Alvaro.

In: European Spine Journal, Vol. 18, No. SUPPL. 2, 07.2009.

Research output: Contribution to journalArticle

Marucci, Gianluca ; Barbanera, Andrea ; Serchi, Elena ; Andreoli, Alvaro. / Ganglioneurocytoma of the spinal cord : Report of a case and review of literature. In: European Spine Journal. 2009 ; Vol. 18, No. SUPPL. 2.
@article{5b1d16bc6bec4ee2911dfdb147a057a6,
title = "Ganglioneurocytoma of the spinal cord: Report of a case and review of literature",
abstract = "A case of ganglioneurocytoma of the spinal cord in a 51-year-old man is reported. Patient presented with a progressively worsening back pain and hyposthenia of lower limbs. Magnetic resonance imaging of the spinal cord revealed an intradural lesion in the T10-11 spinal segments, hyperintense on T1-weighted sequences. Complete resection was achieved. The patient did not show evidence of recurrence 12 months after surgery. On histology, the lesion was composed of round to oval cells with fine granular, slightly eosinophilic to clear cytoplasm suggesting a neurocytic differentiation. Some ganglion cells were observed. Neither significant cytologic atypia nor mitoses were present. The neoplastic cells were strongly positive with synaptophysin and negative with glial fibrillary acid protein. Neurocytomas are uncommon tumors typically arising within the lateral ventricles near the foramen of Monro. Extraventricular neurocytomas have been reported at various sites with rare examples in spinal cord. In the present paper, a case of ganglioneurocytoma of the spinal cord is reported with review of literature and discussion of differences compared to neurocytomas of other sites.",
keywords = "Extraventricular neurocytoma, Ganglioneurocytoma, Neurocytic differentiation, Neurocytoma, Spinal cord",
author = "Gianluca Marucci and Andrea Barbanera and Elena Serchi and Alvaro Andreoli",
year = "2009",
month = "7",
doi = "10.1007/s00586-008-0785-8",
language = "English",
volume = "18",
journal = "European Spine Journal",
issn = "0940-6719",
publisher = "Springer Verlag",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Ganglioneurocytoma of the spinal cord

T2 - Report of a case and review of literature

AU - Marucci, Gianluca

AU - Barbanera, Andrea

AU - Serchi, Elena

AU - Andreoli, Alvaro

PY - 2009/7

Y1 - 2009/7

N2 - A case of ganglioneurocytoma of the spinal cord in a 51-year-old man is reported. Patient presented with a progressively worsening back pain and hyposthenia of lower limbs. Magnetic resonance imaging of the spinal cord revealed an intradural lesion in the T10-11 spinal segments, hyperintense on T1-weighted sequences. Complete resection was achieved. The patient did not show evidence of recurrence 12 months after surgery. On histology, the lesion was composed of round to oval cells with fine granular, slightly eosinophilic to clear cytoplasm suggesting a neurocytic differentiation. Some ganglion cells were observed. Neither significant cytologic atypia nor mitoses were present. The neoplastic cells were strongly positive with synaptophysin and negative with glial fibrillary acid protein. Neurocytomas are uncommon tumors typically arising within the lateral ventricles near the foramen of Monro. Extraventricular neurocytomas have been reported at various sites with rare examples in spinal cord. In the present paper, a case of ganglioneurocytoma of the spinal cord is reported with review of literature and discussion of differences compared to neurocytomas of other sites.

AB - A case of ganglioneurocytoma of the spinal cord in a 51-year-old man is reported. Patient presented with a progressively worsening back pain and hyposthenia of lower limbs. Magnetic resonance imaging of the spinal cord revealed an intradural lesion in the T10-11 spinal segments, hyperintense on T1-weighted sequences. Complete resection was achieved. The patient did not show evidence of recurrence 12 months after surgery. On histology, the lesion was composed of round to oval cells with fine granular, slightly eosinophilic to clear cytoplasm suggesting a neurocytic differentiation. Some ganglion cells were observed. Neither significant cytologic atypia nor mitoses were present. The neoplastic cells were strongly positive with synaptophysin and negative with glial fibrillary acid protein. Neurocytomas are uncommon tumors typically arising within the lateral ventricles near the foramen of Monro. Extraventricular neurocytomas have been reported at various sites with rare examples in spinal cord. In the present paper, a case of ganglioneurocytoma of the spinal cord is reported with review of literature and discussion of differences compared to neurocytomas of other sites.

KW - Extraventricular neurocytoma

KW - Ganglioneurocytoma

KW - Neurocytic differentiation

KW - Neurocytoma

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=68349158914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68349158914&partnerID=8YFLogxK

U2 - 10.1007/s00586-008-0785-8

DO - 10.1007/s00586-008-0785-8

M3 - Article

C2 - 18813960

AN - SCOPUS:68349158914

VL - 18

JO - European Spine Journal

JF - European Spine Journal

SN - 0940-6719

IS - SUPPL. 2

ER -