Ganglioside and phospholipid patterns in human gastrointestinal tumors

A. Mariano, D. Paduano, A. Di Carlo, V. Macchia

Research output: Contribution to journalArticle

Abstract

Forty-eight human intestinal tumors and twelve human gastric adenocarcinomas were analyzed for their ganglioside and phospholipid composition. In malignant intestinal tissues the total amount of ganglioside lipid-bound sialic acid (LBSA) was higher than that of histologically normal adjacent tissues. The same amount of LBSA was found in peritumoral and cancerous gastric tissue. In all peritumoral gastrointestinal tissues the most abundant gangliosides were GD1a, GD3, GD1b and GM1. GM3, GM2 and GT1b were present in small amounts. There was a similar ganglioside pattern in gastrointestinal tumor tissue except that GD3 was increased and GD1b and GD1a were decreased. Total phospholipids were higher in the intestinal than in peritumoral tissue. There was no difference in the content of total phospholipid between gastric cancers and peritumoral tissues. The major phospholipid components in both peritumoral and tumoral tissues were lecithin and phosphatidylethanolamine; in minor amounts phosphatidylinositol, sphingomyelin, phosphatidylserine and lysolecithin. The amount of sphingomyelin was slightly higher in tumoral tissue than in peritumoral tissue.

Original languageEnglish
Pages (from-to)115-126
Number of pages12
JournalBulletin of Molecular Biology and Medicine
Volume19
Issue number2-4
Publication statusPublished - 1994

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Gangliosides
Tumors
Phospholipids
Tissue
Neoplasms
Sphingomyelins
N-Acetylneuraminic Acid
Stomach
Lipids
Lysophosphatidylcholines
Lecithins
Phosphatidylserines
Phosphatidylinositols
Stomach Neoplasms
Adenocarcinoma

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Mariano, A., Paduano, D., Di Carlo, A., & Macchia, V. (1994). Ganglioside and phospholipid patterns in human gastrointestinal tumors. Bulletin of Molecular Biology and Medicine, 19(2-4), 115-126.

Ganglioside and phospholipid patterns in human gastrointestinal tumors. / Mariano, A.; Paduano, D.; Di Carlo, A.; Macchia, V.

In: Bulletin of Molecular Biology and Medicine, Vol. 19, No. 2-4, 1994, p. 115-126.

Research output: Contribution to journalArticle

Mariano, A, Paduano, D, Di Carlo, A & Macchia, V 1994, 'Ganglioside and phospholipid patterns in human gastrointestinal tumors', Bulletin of Molecular Biology and Medicine, vol. 19, no. 2-4, pp. 115-126.
Mariano, A. ; Paduano, D. ; Di Carlo, A. ; Macchia, V. / Ganglioside and phospholipid patterns in human gastrointestinal tumors. In: Bulletin of Molecular Biology and Medicine. 1994 ; Vol. 19, No. 2-4. pp. 115-126.
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