Ganglioside lactones: 1H-NMR determination of the inner ester position of GD1b-ganglioside lactone naturally occurring in human brain or produced by chemical synthesis

Domenico Acquotti, Giovanni Fronza, Laura Riboni, Sandro Sonnino, Guido Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

The complete definition of the chemical structure of GD1b-ganglioside (GD1b) lactone isolated from human brain has been given by means of spectrometric and spectroscopic analyses. GD1h lactone contains a single ester linkage involving the external sialic acid carboxyl group and the C-9 hydroxyl group of the internal sialic acid unit. A synthetic lactone of GD1b prepared treating GD1b with glacial acetic acid characterized in the same way showed an identical chemical structure.

Original languageEnglish
Pages (from-to)119-127
Number of pages9
JournalGlycoconjugate Journal
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 1987

Keywords

  • ganglioside lactones
  • NMR

ASJC Scopus subject areas

  • Biochemistry

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