Ganglioside lactones: 1H-NMR determination of the inner ester position of GD1b-ganglioside lactone naturally occurring in human brain or produced by chemical synthesis

Domenico Acquotti; Giovanni Fronza; Laura Riboni; Sandro Sonnino; Guido Tettamanti

doi:10.1007/BF01049450

Ganglioside lactones: 1H-NMR determination of the inner ester position of GD1b-ganglioside lactone naturally occurring in human brain or produced by chemical synthesis

Domenico Acquotti, Giovanni Fronza, Laura Riboni, Sandro Sonnino, Guido Tettamanti

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

The complete definition of the chemical structure of G_D1b-ganglioside (G_D1b) lactone isolated from human brain has been given by means of spectrometric and spectroscopic analyses. G_D1h lactone contains a single ester linkage involving the external sialic acid carboxyl group and the C-9 hydroxyl group of the internal sialic acid unit. A synthetic lactone of G_D1b prepared treating G_D1b with glacial acetic acid characterized in the same way showed an identical chemical structure.

Original language	English
Pages (from-to)	119-127
Number of pages	9
Journal	Glycoconjugate Journal
Volume	4
Issue number	2
DOIs	https://doi.org/10.1007/BF01049450
Publication status	Published - Jun 1987

Keywords

ganglioside lactones
NMR

ASJC Scopus subject areas

Biochemistry

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10.1007/BF01049450

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title = "Ganglioside lactones: 1H-NMR determination of the inner ester position of GD1b-ganglioside lactone naturally occurring in human brain or produced by chemical synthesis",

abstract = "The complete definition of the chemical structure of GD1b-ganglioside (GD1b) lactone isolated from human brain has been given by means of spectrometric and spectroscopic analyses. GD1h lactone contains a single ester linkage involving the external sialic acid carboxyl group and the C-9 hydroxyl group of the internal sialic acid unit. A synthetic lactone of GD1b prepared treating GD1b with glacial acetic acid characterized in the same way showed an identical chemical structure.",

keywords = "ganglioside lactones, NMR",

author = "Domenico Acquotti and Giovanni Fronza and Laura Riboni and Sandro Sonnino and Guido Tettamanti",

year = "1987",

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doi = "10.1007/BF01049450",

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AU - Acquotti, Domenico

AU - Fronza, Giovanni

AU - Riboni, Laura

AU - Sonnino, Sandro

AU - Tettamanti, Guido

PY - 1987/6

Y1 - 1987/6

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AB - The complete definition of the chemical structure of GD1b-ganglioside (GD1b) lactone isolated from human brain has been given by means of spectrometric and spectroscopic analyses. GD1h lactone contains a single ester linkage involving the external sialic acid carboxyl group and the C-9 hydroxyl group of the internal sialic acid unit. A synthetic lactone of GD1b prepared treating GD1b with glacial acetic acid characterized in the same way showed an identical chemical structure.

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KW - NMR

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Ganglioside lactones: 1H-NMR determination of the inner ester position of GD1b-ganglioside lactone naturally occurring in human brain or produced by chemical synthesis

Abstract

Keywords

ASJC Scopus subject areas

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