Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

F. Nicoletti, B. Cavallaro, V. Bruno, M. Virgili, M. V. Catania, A. Contestabile, P. L. Canonico

Research output: Contribution to journalArticle

Abstract

Release of both D-[3H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.

Original languageEnglish
Pages (from-to)1283-1286
Number of pages4
JournalNeuropharmacology
Volume28
Issue number11
DOIs
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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