Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

F. Nicoletti, B. Cavallaro, V. Bruno, M. Virgili, M. V. Catania, A. Contestabile, P. L. Canonico

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Release of both D-[3H]aspartate and endogenous amino acids uas measured in primary cultures of cerebellargranule cells.Tuo hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuatedthestimulation of excitatory amino acid release induced by depolarizing concentrations of K- (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarizationinduced release, i.e. the amplification of release that follous activation of NMDA receptorsby the endogenous glutamate.

Original languageEnglish
Pages (from-to)1283-1286
Number of pages4
JournalNeuropharmacology
Volume28
Issue number11
DOIs
Publication statusPublished - 1989

Fingerprint

D-Aspartic Acid
Phencyclidine
Glycosphingolipids
Excitatory Amino Acids
Primary Cell Culture
Gangliosides
Glutamate Receptors
N-Methylaspartate
Glutamic Acid
Neurons
Amino Acids

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons. / Nicoletti, F.; Cavallaro, B.; Bruno, V.; Virgili, M.; Catania, M. V.; Contestabile, A.; Canonico, P. L.

In: Neuropharmacology, Vol. 28, No. 11, 1989, p. 1283-1286.

Research output: Contribution to journalArticle

Nicoletti, F. ; Cavallaro, B. ; Bruno, V. ; Virgili, M. ; Catania, M. V. ; Contestabile, A. ; Canonico, P. L. / Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons. In: Neuropharmacology. 1989 ; Vol. 28, No. 11. pp. 1283-1286.
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AU - Canonico, P. L.

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