Gas chromatographic determination of acenocoumarin in human plasma

G. Bianchetti; R. Latini; P. L. Morselli

doi:10.1016/S0021-9673(00)89748-4

Gas chromatographic determination of acenocoumarin in human plasma

G. Bianchetti, R. Latini, P. L. Morselli

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

A method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography with electron-capture detection has been developed for the determination of acenocoumarin in plasma. The specificity and sensitivity of the procedure appear to be satisfactory for drug level measurements in human plasma. Its relative simplicity permits its use in routine analysis.

Original language	English
Pages (from-to)	331-335
Number of pages	5
Journal	Journal of Chromatography A
Volume	124
Issue number	2
DOIs	https://doi.org/10.1016/S0021-9673(00)89748-4
Publication status	Published - Sep 15 1976

ASJC Scopus subject areas

Analytical Chemistry
Clinical Biochemistry
Molecular Medicine

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10.1016/S0021-9673(00)89748-4

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abstract = "A method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography with electron-capture detection has been developed for the determination of acenocoumarin in plasma. The specificity and sensitivity of the procedure appear to be satisfactory for drug level measurements in human plasma. Its relative simplicity permits its use in routine analysis.",

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AU - Morselli, P. L.

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N2 - A method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography with electron-capture detection has been developed for the determination of acenocoumarin in plasma. The specificity and sensitivity of the procedure appear to be satisfactory for drug level measurements in human plasma. Its relative simplicity permits its use in routine analysis.

AB - A method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography with electron-capture detection has been developed for the determination of acenocoumarin in plasma. The specificity and sensitivity of the procedure appear to be satisfactory for drug level measurements in human plasma. Its relative simplicity permits its use in routine analysis.

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Gas chromatographic determination of acenocoumarin in human plasma

Abstract

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