Gas chromatographic determination of two fluorinated benzodiazepines in rats and mice

F. Marcucci, L. Garbagna, F. Monti, P. Bonazzi, L. Canobbio, E. Zuccato, E. Mussini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This paper describes a very sensitive gas chromatographic (GC) method to measure the levels of SAS 643 and SAS 646 in biological samples from rats and mice. The two compounds can be detected without any derivatization, but with poor sensitivity because of their polar groups. We have therefore derivatized the molecules in order to obtain better sensitivity in the nanogram range.

Original languageEnglish
Title of host publicationJournal of Chromatography
Pages180-184
Number of pages5
Volume198
Edition2
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine

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