Gas diffusion and alveolar-capillary unit in chronic heart failure

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Abstract

Aims: Alveolar gas diffusion (DLCO) is impaired in chronic heart failure (CHF). Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown. Methods and results: We measured pulmonary function, including DLCO, DM, VC, and alveolar volume (VA), in 191 CHF patients in NYHA class I-III. CHF patients were grouped accordingly to peak exercise oxygen uptake (pVO2): group 20 (n=27). DLCO, DM, VC, and VA were lowest in severe CHF and were linearly related to pV̇O 2 (DLCO, r=0.577, P20 (0.46±0.29), compared with 12-16 (0.34±0.19) and 16-20 (0.35±0.17). Conclusion: DLCO progressively worsens as CHF severity increases due to reduction in lung tissue participating to gas exchange (low VC and VA). In severe CHF, the few working alveolar-capillary units are the most efficient as shown by the high DM/VC. This is useful for maintaining gas exchange efficiency in severe CHF.

Original languageEnglish
Pages (from-to)2538-2543
Number of pages6
JournalEuropean Heart Journal
Volume27
Issue number21
DOIs
Publication statusPublished - Nov 2006

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Heart Failure
Gases
Lung
Exercise
Oxygen
Membranes

Keywords

  • Exercise
  • Heart failure
  • Lung
  • Oedema
  • Ventilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Gas diffusion and alveolar-capillary unit in chronic heart failure",
abstract = "Aims: Alveolar gas diffusion (DLCO) is impaired in chronic heart failure (CHF). Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown. Methods and results: We measured pulmonary function, including DLCO, DM, VC, and alveolar volume (VA), in 191 CHF patients in NYHA class I-III. CHF patients were grouped accordingly to peak exercise oxygen uptake (pVO2): group 20 (n=27). DLCO, DM, VC, and VA were lowest in severe CHF and were linearly related to pV̇O 2 (DLCO, r=0.577, P20 (0.46±0.29), compared with 12-16 (0.34±0.19) and 16-20 (0.35±0.17). Conclusion: DLCO progressively worsens as CHF severity increases due to reduction in lung tissue participating to gas exchange (low VC and VA). In severe CHF, the few working alveolar-capillary units are the most efficient as shown by the high DM/VC. This is useful for maintaining gas exchange efficiency in severe CHF.",
keywords = "Exercise, Heart failure, Lung, Oedema, Ventilation",
author = "Piergiuseppe Agostoni and Maurizio Bussotti and Gaia Cattadori and Eliana Margutti and Mauro Contini and Manuela Muratori and Giancarlo Marenzi and Cesare Fiorentini",
year = "2006",
month = "11",
doi = "10.1093/eurheartj/ehl302",
language = "English",
volume = "27",
pages = "2538--2543",
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TY - JOUR

T1 - Gas diffusion and alveolar-capillary unit in chronic heart failure

AU - Agostoni, Piergiuseppe

AU - Bussotti, Maurizio

AU - Cattadori, Gaia

AU - Margutti, Eliana

AU - Contini, Mauro

AU - Muratori, Manuela

AU - Marenzi, Giancarlo

AU - Fiorentini, Cesare

PY - 2006/11

Y1 - 2006/11

N2 - Aims: Alveolar gas diffusion (DLCO) is impaired in chronic heart failure (CHF). Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown. Methods and results: We measured pulmonary function, including DLCO, DM, VC, and alveolar volume (VA), in 191 CHF patients in NYHA class I-III. CHF patients were grouped accordingly to peak exercise oxygen uptake (pVO2): group 20 (n=27). DLCO, DM, VC, and VA were lowest in severe CHF and were linearly related to pV̇O 2 (DLCO, r=0.577, P20 (0.46±0.29), compared with 12-16 (0.34±0.19) and 16-20 (0.35±0.17). Conclusion: DLCO progressively worsens as CHF severity increases due to reduction in lung tissue participating to gas exchange (low VC and VA). In severe CHF, the few working alveolar-capillary units are the most efficient as shown by the high DM/VC. This is useful for maintaining gas exchange efficiency in severe CHF.

AB - Aims: Alveolar gas diffusion (DLCO) is impaired in chronic heart failure (CHF). Diffusion depends on membrane diffusion (DM) and the amount of blood participating in gas exchange (VC). How DM, VC, and the alveolar-capillary unit behave in relationship to CHF severity is unknown. Methods and results: We measured pulmonary function, including DLCO, DM, VC, and alveolar volume (VA), in 191 CHF patients in NYHA class I-III. CHF patients were grouped accordingly to peak exercise oxygen uptake (pVO2): group 20 (n=27). DLCO, DM, VC, and VA were lowest in severe CHF and were linearly related to pV̇O 2 (DLCO, r=0.577, P20 (0.46±0.29), compared with 12-16 (0.34±0.19) and 16-20 (0.35±0.17). Conclusion: DLCO progressively worsens as CHF severity increases due to reduction in lung tissue participating to gas exchange (low VC and VA). In severe CHF, the few working alveolar-capillary units are the most efficient as shown by the high DM/VC. This is useful for maintaining gas exchange efficiency in severe CHF.

KW - Exercise

KW - Heart failure

KW - Lung

KW - Oedema

KW - Ventilation

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