Gas distribution in a two-compartment model during volume or pressure ventilation: Role of elastic elements

Vittorio Antonaglia, Umberto Lucangelo, Giuseppe Ristagno, Simona Tantillo, Massimo Ferluga, Lorenzo Torelli, Walter A. Zin

Research output: Contribution to journalArticle

Abstract

The results of the studies on pulmonary gas distribution during constant-flow controlled-volume inflation (VCV) and inspiratory constant pressure inflation (PCV) in experimental studies are conflicting. In a mathematical model, with the characteristics of two lung compartments including tissue viscoelastic properties, pulmonary gas distribution was tested by simulating PCV and VCV at same inflation volumes. The compartmental distributions of the tidal volume were compared during CMV and PCV in different configurations obtained by changing the elastic and viscoelastic properties in each compartment, but maintaining the same total values of respiratory mechanics measured in patients. In all instances PCV resulted in a slightly higher air-trapping than in VCV mode. Heterogeneous elastic properties diverted most of the tidal volume towards the less compromised compartment. However, both ventilatory modes provided similar compartmental gas distribution, but during VCV compartmental peak pressures were higher in the sicker compartment respect to PCV. The use of PCV could grant a less remarkable pressure variability able to reduce the potential ventilator-associated lung injury. Moreover, the parameters measured during an end-inspiratory pause could not pinpoint unique characteristics for each configuration.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume171
Issue number3
DOIs
Publication statusPublished - May 31 2010

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Economic Inflation
Ventilation
Gases
Tidal Volume
Pressure
Lung
Respiratory Mechanics
Lung Injury
Mechanical Ventilators
Theoretical Models
Air

Keywords

  • Elastic and viscoelastic properties
  • Gas distribution
  • Inflation
  • Ventilation mode

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Gas distribution in a two-compartment model during volume or pressure ventilation : Role of elastic elements. / Antonaglia, Vittorio; Lucangelo, Umberto; Ristagno, Giuseppe; Tantillo, Simona; Ferluga, Massimo; Torelli, Lorenzo; Zin, Walter A.

In: Respiratory Physiology and Neurobiology, Vol. 171, No. 3, 31.05.2010, p. 225-231.

Research output: Contribution to journalArticle

Antonaglia, Vittorio ; Lucangelo, Umberto ; Ristagno, Giuseppe ; Tantillo, Simona ; Ferluga, Massimo ; Torelli, Lorenzo ; Zin, Walter A. / Gas distribution in a two-compartment model during volume or pressure ventilation : Role of elastic elements. In: Respiratory Physiology and Neurobiology. 2010 ; Vol. 171, No. 3. pp. 225-231.
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