GAS6, the ligand of Axl and Rse receptors, is expressed in hematopoietic tissue but lacks mitogenic activity

G. C. Avanzi, M. Gallicchio, G. Cavalloni, L. Gammaitoni, F. Leone, A. Rosina, R. Boldorini, G. Monga, L. Pegoraro, B. Varnum, M. Aglietta

Research output: Contribution to journalArticle

Abstract

GAS6, a gene previously identified as growth arrest specific, has been demonstrated to be the ligand of Axl, a novel tyrosine kinase receptor widely expressed in both normal and neoplastic hematopoietic tissue. We have observed previously that GAS6 mRNA was present in whole bone marrow. This preliminary finding prompted us to investigate the presence of GAS6 in hematopoietic tissue and the possible role of this molecule in controlling the proliferation of hematopoietic precursors. We report here that the protein GAS6 is diffusely present in hematopoietic tissue, both in stromal and in hematopoietic cells, and that, among these cells, positivity is observed in megakaryocytes and myelomonocytic precursors. Furthermore, our data suggest that GAS6 is not a growth factor for hematopoietic progenitors or stromal fibroblasts. Despite the fact that both the Axl receptor and its ligand, GAS6, are expressed in hematopoietic tissue, the biological role of their interactions remains to be determined.

Original languageEnglish
Pages (from-to)1219-1226
Number of pages8
JournalExperimental Hematology
Volume25
Issue number12
Publication statusPublished - 1997

Keywords

  • GAS6
  • Hematopoiesis
  • Receptor tyrosine kinase

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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