Gastric cancer (GC) is a well known topic: in fact, its morphology, epidemiology and etiopathogenesis have been widely and exhaustively reported in literature. Surprisingly, although recent news about the involvement of Helicobacter pylori in GC pathology has a great potential for enhancing prevention and monitoring patients at risk, incidence of and mortality from the disease have been scarcely influenced by the progress made in GC knowledge. The authors discuss the literature about morphology, epidemiology and etiopathogenesis of GC with special regard to the findings which are most important from a clinical point of view. As regards morphology, the present review takes into consideration three topics in particular: the changing pattern of GC, the increasing importance of an accurate Staging, and some interesting developments in histological Grading. As far as epidemiology is concerned, it focuses on the unexplained decline in GC incidence and mortality, both in the world and in Italy. Finally, advances in the knowledge of GC etiopathogenesis are examined in the light of Lauren's classification and of Morson's definition of gastric dysplasia; attention is devoted to the different etiologic factors of GC with special regard to Helicobacter pylori. Our paper aims at increasing the clinician's awareness of the recent advances in GC knowledge in order to speed up progress in the diagnosis and treatment of this elusive malignancy.
|Translated title of the contribution||Gastric cancer: A revaluation and new perspectives|
|Number of pages||14|
|Journal||Giornale Italiano di Endoscopia Digestiva|
|Publication status||Published - 1997|
ASJC Scopus subject areas