Gastric carcinoids of argyrophil ECL cells

Carlo Capella, Julia M. Polak, Catherine M. Timson, Bruno Frigerio, Enrico Solcia

Research output: Contribution to journalArticle

Abstract

Histochemical and ultrastructural studies were carried out in four gastric carcinoids, two of which were associated with atrophic gastritis and pernicious anemia. All tumors showed intense argyrophilia and vesicular granules resembling those of endocrine enterochromaffinlike (ECL) cells in normal human gastric mucosa. Tumor cells were found to be unreactive to all the 18 available antiserums to gut hormones, including gastrin, somatostatin, glucagon, and pancreatic polypeptide. The tumors were interpreted as ECL cell argyrophil carcinoids with various degrees of differentiation and atypia.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalUltrastructural Pathology
Volume1
Issue number3
DOIs
Publication statusPublished - 1980

Keywords

  • ECL cell tumors
  • Gastric carcinoids
  • Histochemistry
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

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  • Cite this

    Capella, C., Polak, J. M., Timson, C. M., Frigerio, B., & Solcia, E. (1980). Gastric carcinoids of argyrophil ECL cells. Ultrastructural Pathology, 1(3), 411-418. https://doi.org/10.3109/01913128009141444