Gastric emptying of solids in patients with nonobstructive crohn’s disease is sometimes delayed

Vito Annese, Gabrio Bassotti, Grazia Napolitano, Vincenzo Frusciante, Michele Bruno, Pasquale Conoscitore, Ugo Germani, Antonio Morelli, Angelo Andriulli

Research output: Contribution to journalArticle

Abstract

To date, only a few studies of gastric emptying in Crohn’s disease have been published in the literature. This might be clinically important because slow-release drug formulations are increasingly available for treatment. Studies in children with gastric involvement suggest that gastric emptying may be delayed in this condition. We studied the scintigraphic gastric emptying of 21 adult patients with nonobstructive Crohn’s disease and without gastric or duodenal involvement by the disease, compared with that of 20 healthy volunteers. Overall, no significant differences were found, but subgroup analysis showed that symptomatic patients [half-time (t½) 133 ± 75.9] and those with colonic involvement (t½ 127.2 ± 64) had a significantly (p <0.01) delayed gastric emptying over controls (t½ 85.5 ± 15.4). Such a difference was also observed between symptomatic and asymptomatic patients (p <0.05). We conclude that gastric emptying is slowed in symptomatic patients with nonobstructive Crohn’s disease and in those with colonic involvement. This may have therapeutic implications.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of Clinical Gastroenterology
Volume21
Issue number4
Publication statusPublished - 1995

Keywords

  • Crohn’s disease
  • Emptying
  • Gastric
  • Motility
  • Scintigraphy

ASJC Scopus subject areas

  • Gastroenterology

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    Annese, V., Bassotti, G., Napolitano, G., Frusciante, V., Bruno, M., Conoscitore, P., Germani, U., Morelli, A., & Andriulli, A. (1995). Gastric emptying of solids in patients with nonobstructive crohn’s disease is sometimes delayed. Journal of Clinical Gastroenterology, 21(4), 279-282.