Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal

F. Perri, M. Pastore, A. Zicolella, V. Annese, M. Quitadamo, A. Andriulli

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Several gastrointestinal motor abnormalities have been detected in patients with celiac disease, but it is unclear whether they are able to influence the gastric emptying rate. The aim of this work was to evaluate the gastric emptying rate of solids in children with celiac disease before and after a gluten-free diet. Nine children with celiac disease and nine healthy controls (age range 4-16 y) underwent a13C-octanoic acid breath test to measure gastric emptying. Half emptying time (t(1/2)) and lag phase (t(lag)) were calculated. After 6 mo of a gluten-free diet, all celiac children underwent a repeat 13C-octanoic acid breath test. The gastric motility parameters, t(1/2) and t(lag), were significantly longer in patients than in controls. No significant correlation between abnormal gastric emptying and specific symptom patterns or severity of histological damage was found. On a gluten-free diet, the gastric emptying rate normalized in all celiac patients. This finding supports the hypothesis that gluten-driven mucosal inflammation might determine motor abnormalities by affecting smooth muscle contractility or impairing the release of neurotransmitters. Alternatively, nutrient malabsorption might determine significant changes in intraluminal milieu, which, in turn, may affect intestinal motor functions. Conclusion: patients affected by celiac disease have a markedly delayed gastric emptying of solids, which returns to normal after gluten withdrawal.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume89
Issue number8
Publication statusPublished - 2000

Fingerprint

Glutens
Gastric Emptying
Celiac Disease
Gluten-Free Diet
Breath Tests
Abdomen
Smooth Muscle
Neurotransmitter Agents
Stomach
Inflammation
Food

Keywords

  • 13C-octanoic acid
  • Breath test
  • Celiac disease
  • Gastric emptying
  • Gluten

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal. / Perri, F.; Pastore, M.; Zicolella, A.; Annese, V.; Quitadamo, M.; Andriulli, A.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 89, No. 8, 2000, p. 921-925.

Research output: Contribution to journalArticle

Perri, F. ; Pastore, M. ; Zicolella, A. ; Annese, V. ; Quitadamo, M. ; Andriulli, A. / Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal. In: Acta Paediatrica, International Journal of Paediatrics. 2000 ; Vol. 89, No. 8. pp. 921-925.
@article{00a9de28a66947a6b4b4cdbfb8ea45d2,
title = "Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal",
abstract = "Several gastrointestinal motor abnormalities have been detected in patients with celiac disease, but it is unclear whether they are able to influence the gastric emptying rate. The aim of this work was to evaluate the gastric emptying rate of solids in children with celiac disease before and after a gluten-free diet. Nine children with celiac disease and nine healthy controls (age range 4-16 y) underwent a13C-octanoic acid breath test to measure gastric emptying. Half emptying time (t(1/2)) and lag phase (t(lag)) were calculated. After 6 mo of a gluten-free diet, all celiac children underwent a repeat 13C-octanoic acid breath test. The gastric motility parameters, t(1/2) and t(lag), were significantly longer in patients than in controls. No significant correlation between abnormal gastric emptying and specific symptom patterns or severity of histological damage was found. On a gluten-free diet, the gastric emptying rate normalized in all celiac patients. This finding supports the hypothesis that gluten-driven mucosal inflammation might determine motor abnormalities by affecting smooth muscle contractility or impairing the release of neurotransmitters. Alternatively, nutrient malabsorption might determine significant changes in intraluminal milieu, which, in turn, may affect intestinal motor functions. Conclusion: patients affected by celiac disease have a markedly delayed gastric emptying of solids, which returns to normal after gluten withdrawal.",
keywords = "13C-octanoic acid, Breath test, Celiac disease, Gastric emptying, Gluten",
author = "F. Perri and M. Pastore and A. Zicolella and V. Annese and M. Quitadamo and A. Andriulli",
year = "2000",
language = "English",
volume = "89",
pages = "921--925",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Gastric emptying of solids is delayed in celiac disease and normalizes after gluten withdrawal

AU - Perri, F.

AU - Pastore, M.

AU - Zicolella, A.

AU - Annese, V.

AU - Quitadamo, M.

AU - Andriulli, A.

PY - 2000

Y1 - 2000

N2 - Several gastrointestinal motor abnormalities have been detected in patients with celiac disease, but it is unclear whether they are able to influence the gastric emptying rate. The aim of this work was to evaluate the gastric emptying rate of solids in children with celiac disease before and after a gluten-free diet. Nine children with celiac disease and nine healthy controls (age range 4-16 y) underwent a13C-octanoic acid breath test to measure gastric emptying. Half emptying time (t(1/2)) and lag phase (t(lag)) were calculated. After 6 mo of a gluten-free diet, all celiac children underwent a repeat 13C-octanoic acid breath test. The gastric motility parameters, t(1/2) and t(lag), were significantly longer in patients than in controls. No significant correlation between abnormal gastric emptying and specific symptom patterns or severity of histological damage was found. On a gluten-free diet, the gastric emptying rate normalized in all celiac patients. This finding supports the hypothesis that gluten-driven mucosal inflammation might determine motor abnormalities by affecting smooth muscle contractility or impairing the release of neurotransmitters. Alternatively, nutrient malabsorption might determine significant changes in intraluminal milieu, which, in turn, may affect intestinal motor functions. Conclusion: patients affected by celiac disease have a markedly delayed gastric emptying of solids, which returns to normal after gluten withdrawal.

AB - Several gastrointestinal motor abnormalities have been detected in patients with celiac disease, but it is unclear whether they are able to influence the gastric emptying rate. The aim of this work was to evaluate the gastric emptying rate of solids in children with celiac disease before and after a gluten-free diet. Nine children with celiac disease and nine healthy controls (age range 4-16 y) underwent a13C-octanoic acid breath test to measure gastric emptying. Half emptying time (t(1/2)) and lag phase (t(lag)) were calculated. After 6 mo of a gluten-free diet, all celiac children underwent a repeat 13C-octanoic acid breath test. The gastric motility parameters, t(1/2) and t(lag), were significantly longer in patients than in controls. No significant correlation between abnormal gastric emptying and specific symptom patterns or severity of histological damage was found. On a gluten-free diet, the gastric emptying rate normalized in all celiac patients. This finding supports the hypothesis that gluten-driven mucosal inflammation might determine motor abnormalities by affecting smooth muscle contractility or impairing the release of neurotransmitters. Alternatively, nutrient malabsorption might determine significant changes in intraluminal milieu, which, in turn, may affect intestinal motor functions. Conclusion: patients affected by celiac disease have a markedly delayed gastric emptying of solids, which returns to normal after gluten withdrawal.

KW - 13C-octanoic acid

KW - Breath test

KW - Celiac disease

KW - Gastric emptying

KW - Gluten

UR - http://www.scopus.com/inward/record.url?scp=0033901765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033901765&partnerID=8YFLogxK

M3 - Article

C2 - 10976830

AN - SCOPUS:0033901765

VL - 89

SP - 921

EP - 925

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 8

ER -