Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori: Scratch and win

Monica Franco, Massimo Rugge, Emma D'Andrea, Claudia Mescoli, Chiara Menin, Fabio Farinati

Research output: Contribution to journalArticle

Abstract

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with Helicobacter pylori infection and, in the great majority of patients, regresses after eradication. H. pylori-negative MALT lymphoma occurs in a small minority of cases in which treatment is based on surgery or chemoradiotherapy. In the search for H. pylori based on histology and the C 13 urea breath test, this report describes a case with a series of false-negative results, thus confirming the possibility of a lower detectability of H. pylori in patients with MALT gastric lymphoma and supporting the use of additional tests in evaluating such pathology, including polymerase chain reaction. Additionally, treatment with CD20 monoclonal antibody (rituximab) is suggested as an alternative to surgery or treatment with chemotherapy or radiotherapy in patients with truly H. pylori-negative gastric MALT lymphoma.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • CD20 monoclonal antibody
  • Helicobacter pylori
  • MALT lymphoma

ASJC Scopus subject areas

  • Gastroenterology

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