Abstract
138 consecutive patients with endoscopically and histologically confirmed benign gastric ulcer were investigated in order to evaluate the relationship between aging and parameters relating to gastric ulcer pathophysiology and natural history: prevalence in dyspeptic patients referred to an endoscopic unit, recurrences, gastric acid secretory capacity, peptic activity, incidence of precancerous and neoplastic changes. On the basis of our results, different populations of gastric ulcer patients seem to be identifiable: (1) young patients (aged under 40), with low prevalence and recurrence rates, with acid capacity above normal range, high peptic activity and no risk for precancerous or neoplastic changes, (2) middle-aged subjects (41–50), with high prevalence and recurrence rates, high peptic activity and acid activity within the normal range, atrophic gastritis, intestinal metaplasia, dysplasia and low incidence of cancer, and (3) elderly patients (aged over 50), with lower prevalence and recurrence rates, frequent association with chronic atrophic gastritis, impaired acid and peptic secretion, in whom one may observe either an association of the ulceration with cancer or evolution of dysplasia into neoplasia. These observations confirm that elderly and middle-aged gastric ulcer patients should undergo routine follow-up, and that pathophysiological data should be taken into account before deciding upon antiulcer therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 297-303 |
| Number of pages | 7 |
| Journal | Gerontology |
| Volume | 34 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 1988 |
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Keywords
- Gastric epithelial dysplasia
- Gastric mucosa
- Gastric ulcer
- Precancerous conditions
- Stomach cancer
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Gastric ulcer and stomach aging : Pathophysiology and clinical implications. / Farinati, Fabio; Cardin, F.; Di Mario, F.; Battaglia, G.; Cannizzaro, R.; Penon, G.; Naccarato, R.
In: Gerontology, Vol. 34, No. 5-6, 1988, p. 297-303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastric ulcer and stomach aging
T2 - Pathophysiology and clinical implications
AU - Farinati, Fabio
AU - Cardin, F.
AU - Di Mario, F.
AU - Battaglia, G.
AU - Cannizzaro, R.
AU - Penon, G.
AU - Naccarato, R.
PY - 1988
Y1 - 1988
N2 - 138 consecutive patients with endoscopically and histologically confirmed benign gastric ulcer were investigated in order to evaluate the relationship between aging and parameters relating to gastric ulcer pathophysiology and natural history: prevalence in dyspeptic patients referred to an endoscopic unit, recurrences, gastric acid secretory capacity, peptic activity, incidence of precancerous and neoplastic changes. On the basis of our results, different populations of gastric ulcer patients seem to be identifiable: (1) young patients (aged under 40), with low prevalence and recurrence rates, with acid capacity above normal range, high peptic activity and no risk for precancerous or neoplastic changes, (2) middle-aged subjects (41–50), with high prevalence and recurrence rates, high peptic activity and acid activity within the normal range, atrophic gastritis, intestinal metaplasia, dysplasia and low incidence of cancer, and (3) elderly patients (aged over 50), with lower prevalence and recurrence rates, frequent association with chronic atrophic gastritis, impaired acid and peptic secretion, in whom one may observe either an association of the ulceration with cancer or evolution of dysplasia into neoplasia. These observations confirm that elderly and middle-aged gastric ulcer patients should undergo routine follow-up, and that pathophysiological data should be taken into account before deciding upon antiulcer therapy.
AB - 138 consecutive patients with endoscopically and histologically confirmed benign gastric ulcer were investigated in order to evaluate the relationship between aging and parameters relating to gastric ulcer pathophysiology and natural history: prevalence in dyspeptic patients referred to an endoscopic unit, recurrences, gastric acid secretory capacity, peptic activity, incidence of precancerous and neoplastic changes. On the basis of our results, different populations of gastric ulcer patients seem to be identifiable: (1) young patients (aged under 40), with low prevalence and recurrence rates, with acid capacity above normal range, high peptic activity and no risk for precancerous or neoplastic changes, (2) middle-aged subjects (41–50), with high prevalence and recurrence rates, high peptic activity and acid activity within the normal range, atrophic gastritis, intestinal metaplasia, dysplasia and low incidence of cancer, and (3) elderly patients (aged over 50), with lower prevalence and recurrence rates, frequent association with chronic atrophic gastritis, impaired acid and peptic secretion, in whom one may observe either an association of the ulceration with cancer or evolution of dysplasia into neoplasia. These observations confirm that elderly and middle-aged gastric ulcer patients should undergo routine follow-up, and that pathophysiological data should be taken into account before deciding upon antiulcer therapy.
KW - Gastric epithelial dysplasia
KW - Gastric mucosa
KW - Gastric ulcer
KW - Precancerous conditions
KW - Stomach cancer
UR - http://www.scopus.com/inward/record.url?scp=0024271298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024271298&partnerID=8YFLogxK
U2 - 10.1159/000212970
DO - 10.1159/000212970
M3 - Article
C2 - 3220264
AN - SCOPUS:0024271298
VL - 34
SP - 297
EP - 303
JO - Gerontology
JF - Gerontology
SN - 0304-324X
IS - 5-6
ER -