Gastrin cell hyperplasia in childhood helicobacter pylori gastritis

Giuseppina Oderda, Roberto Fiocca, Laura Villani, Franco Altare, Isabella Morra, Nicoletta Ansaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To study the relationship between hypergastrinaemia and gastrin cell number in antral mucosa of children with Helicobacter pylori gastritis. Patients: Forty-two children were involved, 16 of whom had H. pylori gastritis, 15 had no gastric pathology (controls) and 11 had been treated with antibiotics 1 month previously. Design: Antral biopsies were taken during endoscopy. Well oriented sections were immunostained with anti-gastrin 34 antiserum and positive cells were counted per linear millimetre of mucosa. Serum gastrin was measured by radioimmunoassay. Results: Serum gastrin was significantly higher in H. pylori-positive children and median (±1 SD) gastrin cell number was significantly increased (140±39 versus 119±24 in controls, P

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume5
Issue number1
Publication statusPublished - 1993

Keywords

  • Gastrin
  • gastrin cells
  • gastritis
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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