Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications

Mikko O. Laukkanen; Maria Domenica Castellone

Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications

Mikko O. Laukkanen, Maria Domenica Castellone

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.

Original language	English
Pages (from-to)	508-514
Number of pages	7
Journal	Current Drug Targets
Volume	17
Issue number	5
Publication status	Published - Apr 1 2016

Keywords

Cancer
Clinical trial
Drug targets
Neuropeptide
Signaling transduction

ASJC Scopus subject areas

Drug Discovery
Pharmacology
Clinical Biochemistry
Molecular Medicine

Cite this

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title = "Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications",

abstract = "Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.",

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author = "Laukkanen, {Mikko O.} and Castellone, {Maria Domenica}",

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T1 - Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment

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AU - Castellone, Maria Domenica

PY - 2016/4/1

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N2 - Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.

AB - Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.

KW - Cancer

KW - Clinical trial

KW - Drug targets

KW - Neuropeptide

KW - Signaling transduction

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JO - Current Drug Targets

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ER -

Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications

Abstract

Keywords

ASJC Scopus subject areas

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