Gastrinoma and neurofibromatosis type 2: The first case report and review of the literature

Sara Massironi, Alessandra Zilli, Roberta E. Rossi, Federica Cavalcoli, Dario Conte, Maddalena Peracchi

Research output: Contribution to journalArticlepeer-review


Background: Gastroenteropancreatic neuroendocrine tumors have occasionally been described in association with neurofibromatosis type 1, whereas an association with neurofibromatosis type 2 has never been reported.Case presentation: This report refers to an Italian 69 year old woman with neurofibromatosis type 2 and a pancreatic gastrinoma. In the past she had encephalic meningiomas, a tongue schwannoma and bilateral acoustic neurinomas. She presented with weight loss and a long-term history of diarrhea, responsive to proton pump inhibitors. Upper gastrointestinal endoscopy revealed peptic ulcer of the duodenal bulb. Blood tests were normal, except for the elevation of plasma gastrin (1031 pg/ml; reference value

Original languageEnglish
Article number110
JournalBMC Gastroenterology
Issue number1
Publication statusPublished - Jun 24 2014


  • Gastrinoma
  • Multiple endocrine neoplasia syndrome type 1
  • Neuroendocrine tumors
  • Neurofibromatosis type 2
  • Zollinger Ellison syndrome

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)


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