Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients

Edoardo Savarino, Roberto Carbone, Elisa Marabotto, Manuele Furnari, Luca Sconfienza, Massimo Ghio, Patrizia Zentilin, Vincenzo Savarino

Research output: Contribution to journalArticlepeer-review


The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibrosis was assessed using validated HRCT scores. Reflux features included distal oesophageal acid exposure, number of acid/weakly acidic reflux episodes and their proximal migration. 40 consecutive patients with interstitial lung disease other than IPF (non-IPF patients) and 50 healthy volunteers were also enrolled. IPF patients had significantly higher (p2=0.567) and proximal (r 2=0.6323) oesophagus. Patients with IPF had more bile acids and pepsin (p

Original languageEnglish
Pages (from-to)1322-1331
Number of pages10
JournalEuropean Respiratory Journal
Issue number5
Publication statusPublished - Nov 1 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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