Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients

Edoardo Savarino; Roberto Carbone; Elisa Marabotto; Manuele Furnari; Luca Sconfienza; Massimo Ghio; Patrizia Zentilin; Vincenzo Savarino

doi:10.1183/09031936.00101212

Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients

Edoardo Savarino, Roberto Carbone, Elisa Marabotto, Manuele Furnari, Luca Sconfienza, Massimo Ghio, Patrizia Zentilin, Vincenzo Savarino

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibrosis was assessed using validated HRCT scores. Reflux features included distal oesophageal acid exposure, number of acid/weakly acidic reflux episodes and their proximal migration. 40 consecutive patients with interstitial lung disease other than IPF (non-IPF patients) and 50 healthy volunteers were also enrolled. IPF patients had significantly higher (p2=0.567) and proximal (r ²=0.6323) oesophagus. Patients with IPF had more bile acids and pepsin (p

Original language	English
Pages (from-to)	1322-1331
Number of pages	10
Journal	European Respiratory Journal
Volume	42
Issue number	5
DOIs	https://doi.org/10.1183/09031936.00101212
Publication status	Published - Nov 1 2013

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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AU - Savarino, Edoardo

AU - Carbone, Roberto

AU - Marabotto, Elisa

AU - Furnari, Manuele

AU - Sconfienza, Luca

AU - Ghio, Massimo

AU - Zentilin, Patrizia

AU - Savarino, Vincenzo

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Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients

Abstract

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