Abstract
The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibrosis was assessed using validated HRCT scores. Reflux features included distal oesophageal acid exposure, number of acid/weakly acidic reflux episodes and their proximal migration. 40 consecutive patients with interstitial lung disease other than IPF (non-IPF patients) and 50 healthy volunteers were also enrolled. IPF patients had significantly higher (p2=0.567) and proximal (r 2=0.6323) oesophagus. Patients with IPF had more bile acids and pepsin (p
Original language | English |
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Pages (from-to) | 1322-1331 |
Number of pages | 10 |
Journal | European Respiratory Journal |
Volume | 42 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 1 2013 |
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine