Helicobacter pylori (HP) causes chronic gastritis in virtually all infected subjects. We have studied the incidence of HP inaction in 46 uremic hemodialysed (HD) patients (pts.) and in 19 renal transplant (tx) recipients with the serum antibody (Ab) IgG title, gastroduodenoscopy (GDS) with gastric biopsy used both for the urea test and for histological processing and bacterial identification (Giemsa). The control groups were represented by 50 subjects and 18 subjects, free from renal disease (healthy blood donors) for the uremic and the transplanted group, respectively. The incidence of HP infection with Ab title was 65% in uremic pts. (vs 65% in the control group) and 44% in transplanted pts. (vs 58%). GDS identified the gastric and duodenal mucosal erosions in only 50%. A correspondence between Ab title and endoscopic lesions was found in 80%. The urea test did not show any correlation with the Ab title. Histological identification was performed in 25 samples; in 20 of them HP was found in the gastric mucosa: in these pts. the correspondence with the Ab title was 100%. There was no statistical correlation between Ab title and the sex of the patients (χ test with Yate's correction) or the duration of HD (Student's test), but there was between the Ab title and the time post transplant (p <0.05, Student's test). Fifteen uremic pts. positive for histological HP identification treated with one week triple therapy (omeprazole 20 mg/day, clarithromycin 250 mg x 2/day, metronidazole 250 mg x 2/day), have reduced their Ab title (33.2%) after six months from therapy (p <0.01 Student's test). This reduction was the same (40%) as that obtained in a control group of non-uremic HP infected pts. after the same therapy.
|Translated title of the contribution||Gastroduodenal disease and Helicobacter pylori (HP) infection in uremic patients in hemodialysis and renal transplant recipients|
|Number of pages||6|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1998|
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