Abstract
The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46% versus 12%), ulcers (29% versus 7%), H. pylori positivity (83% versus 57%), and anti-CagA positivity (66% versus 37%). Fourteen out of 20 (70%) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 198-202 |
| Number of pages | 5 |
| Journal | British Journal of Haematology |
| Volume | 117 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
Fingerprint
Keywords
- CagA
- Gastroduodenal lesions
- Helicobacter pylori
- Myeloproliferative disorders
- Polycythaemia vera
ASJC Scopus subject areas
- Hematology
Cite this
Gastroduodenal lesions in polycythaemia vera : Frequency and role of Helicobacter pylori. / Torgano, Giuseppe; Mandelli, Clara; Massaro, Paolo; Abbiati, Carla; Ponzetto, Antonio; Bertinieri, Giovanni; Bogetto, Stefano Ferrero; Terruzzi, Elisabetta; De Franchis, Roberto.
In: British Journal of Haematology, Vol. 117, No. 1, 2002, p. 198-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastroduodenal lesions in polycythaemia vera
T2 - Frequency and role of Helicobacter pylori
AU - Torgano, Giuseppe
AU - Mandelli, Clara
AU - Massaro, Paolo
AU - Abbiati, Carla
AU - Ponzetto, Antonio
AU - Bertinieri, Giovanni
AU - Bogetto, Stefano Ferrero
AU - Terruzzi, Elisabetta
AU - De Franchis, Roberto
PY - 2002
Y1 - 2002
N2 - The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46% versus 12%), ulcers (29% versus 7%), H. pylori positivity (83% versus 57%), and anti-CagA positivity (66% versus 37%). Fourteen out of 20 (70%) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.
AB - The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46% versus 12%), ulcers (29% versus 7%), H. pylori positivity (83% versus 57%), and anti-CagA positivity (66% versus 37%). Fourteen out of 20 (70%) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.
KW - CagA
KW - Gastroduodenal lesions
KW - Helicobacter pylori
KW - Myeloproliferative disorders
KW - Polycythaemia vera
UR - http://www.scopus.com/inward/record.url?scp=0036227645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036227645&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.2002.03380.x
DO - 10.1046/j.1365-2141.2002.03380.x
M3 - Article
VL - 117
SP - 198
EP - 202
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -