Gastroduodenal lesions in polycythaemia vera

Frequency and role of Helicobacter pylori

Giuseppe Torgano, Clara Mandelli, Paolo Massaro, Carla Abbiati, Antonio Ponzetto, Giovanni Bertinieri, Stefano Ferrero Bogetto, Elisabetta Terruzzi, Roberto De Franchis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46% versus 12%), ulcers (29% versus 7%), H. pylori positivity (83% versus 57%), and anti-CagA positivity (66% versus 37%). Fourteen out of 20 (70%) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalBritish Journal of Haematology
Volume117
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Polycythemia Vera
Helicobacter pylori
Helicobacter Infections
Patient Selection
Multivariate Analysis
Gastrointestinal Endoscopy
Ulcer
Stomach
Western Blotting
Regression Analysis

Keywords

  • CagA
  • Gastroduodenal lesions
  • Helicobacter pylori
  • Myeloproliferative disorders
  • Polycythaemia vera

ASJC Scopus subject areas

  • Hematology

Cite this

Torgano, G., Mandelli, C., Massaro, P., Abbiati, C., Ponzetto, A., Bertinieri, G., ... De Franchis, R. (2002). Gastroduodenal lesions in polycythaemia vera: Frequency and role of Helicobacter pylori. British Journal of Haematology, 117(1), 198-202. https://doi.org/10.1046/j.1365-2141.2002.03380.x

Gastroduodenal lesions in polycythaemia vera : Frequency and role of Helicobacter pylori. / Torgano, Giuseppe; Mandelli, Clara; Massaro, Paolo; Abbiati, Carla; Ponzetto, Antonio; Bertinieri, Giovanni; Bogetto, Stefano Ferrero; Terruzzi, Elisabetta; De Franchis, Roberto.

In: British Journal of Haematology, Vol. 117, No. 1, 2002, p. 198-202.

Research output: Contribution to journalArticle

Torgano, G, Mandelli, C, Massaro, P, Abbiati, C, Ponzetto, A, Bertinieri, G, Bogetto, SF, Terruzzi, E & De Franchis, R 2002, 'Gastroduodenal lesions in polycythaemia vera: Frequency and role of Helicobacter pylori', British Journal of Haematology, vol. 117, no. 1, pp. 198-202. https://doi.org/10.1046/j.1365-2141.2002.03380.x
Torgano, Giuseppe ; Mandelli, Clara ; Massaro, Paolo ; Abbiati, Carla ; Ponzetto, Antonio ; Bertinieri, Giovanni ; Bogetto, Stefano Ferrero ; Terruzzi, Elisabetta ; De Franchis, Roberto. / Gastroduodenal lesions in polycythaemia vera : Frequency and role of Helicobacter pylori. In: British Journal of Haematology. 2002 ; Vol. 117, No. 1. pp. 198-202.
@article{315eca250637491ea281051d6ea1e688,
title = "Gastroduodenal lesions in polycythaemia vera: Frequency and role of Helicobacter pylori",
abstract = "The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46{\%} versus 12{\%}), ulcers (29{\%} versus 7{\%}), H. pylori positivity (83{\%} versus 57{\%}), and anti-CagA positivity (66{\%} versus 37{\%}). Fourteen out of 20 (70{\%}) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.",
keywords = "CagA, Gastroduodenal lesions, Helicobacter pylori, Myeloproliferative disorders, Polycythaemia vera",
author = "Giuseppe Torgano and Clara Mandelli and Paolo Massaro and Carla Abbiati and Antonio Ponzetto and Giovanni Bertinieri and Bogetto, {Stefano Ferrero} and Elisabetta Terruzzi and {De Franchis}, Roberto",
year = "2002",
doi = "10.1046/j.1365-2141.2002.03380.x",
language = "English",
volume = "117",
pages = "198--202",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "1",

}

TY - JOUR

T1 - Gastroduodenal lesions in polycythaemia vera

T2 - Frequency and role of Helicobacter pylori

AU - Torgano, Giuseppe

AU - Mandelli, Clara

AU - Massaro, Paolo

AU - Abbiati, Carla

AU - Ponzetto, Antonio

AU - Bertinieri, Giovanni

AU - Bogetto, Stefano Ferrero

AU - Terruzzi, Elisabetta

AU - De Franchis, Roberto

PY - 2002

Y1 - 2002

N2 - The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46% versus 12%), ulcers (29% versus 7%), H. pylori positivity (83% versus 57%), and anti-CagA positivity (66% versus 37%). Fourteen out of 20 (70%) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.

AB - The prevalence of gastroduodenal lesions is higher in polycythaemia vera (PV) than in the general population. However, the role of Helicobacter pylori (H. pylori) in the pathogenesis of such lesions is unknown. The aim of our study was to evaluate the prevalence of gastroduodenal lesions in PV patients and dyspeptic controls, and to assess the role of PV and H. pylori infection in inducing them. Thirty-five PV patients fulfilling selection criteria and 73 age- and sex-matched controls underwent upper gastrointestinal endoscopy. Six gastric mucosal biopsies were taken in all patients and controls, and analysed for presence of H. pylori; serum anti-CagA was assayed by Western blot. Data were analysed with descriptive statistics and multivariate regression analysis. Compared with controls, PV patients showed a significantly higher frequency of erosions (46% versus 12%), ulcers (29% versus 7%), H. pylori positivity (83% versus 57%), and anti-CagA positivity (66% versus 37%). Fourteen out of 20 (70%) asymptomatic PV patients had gastroduodenal lesions. At multivariate analysis, H. pylori, presence of PV alone, and both PV and anti-CagA were significantly and strongly associated with a higher frequency of gastroduodenal lesions (P <0.05, P <0.01 and P <0.05 respectively). Both PV and H. pylori infection were independent risk factors for gastroduodenal lesions; the underlying pathogenetic mechanism responsible for gastroduodenal lesions in PV possibly involves blood mucosal flow and trophism. The higher susceptibility of H. pylori infection and the high frequency of asymptomatic gastroduodenal lesions in PV patients suggest a surveillance of these patients.

KW - CagA

KW - Gastroduodenal lesions

KW - Helicobacter pylori

KW - Myeloproliferative disorders

KW - Polycythaemia vera

UR - http://www.scopus.com/inward/record.url?scp=0036227645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036227645&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2002.03380.x

DO - 10.1046/j.1365-2141.2002.03380.x

M3 - Article

VL - 117

SP - 198

EP - 202

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -