Gastroenteric neuroendocrine neoplasms classification: Comparison of prognostic models

Anna Dolcetta-Capuzzo, Valentina Villa, Luca Albarello, Giulia M. Franchi, Marco Gemma, Marina Scavini, Saverio Di Palo, Elena Orsenigo, Emanuele Bosi, Claudio Doglioni, Marco F. Manzoni

Research output: Contribution to journalArticlepeer-review


Background: Gastroenteric neuroendocrine neoplasms (GE-NENs) display highly variable clinical behavior. In an attempt to assess a better prognostic description, in 2010, the World Health Organization (WHO) updated its previous classification, and the European Neuroendocrine Tumors Society (ENETS) proposed a new grading and TNM-based staging system. In the current study, the authors evaluated the prognostic significance of these models and compared their efficacy in describing patients' long-term survival to assess the best prognostic model currently available for clinicians. Methods: The study cohort was composed of 145 patients with extrapancreatic GE-NEN who were observed from 1986 to 2008 at a single center and were classified according to the WHO and ENETS classifications. Survival evaluations were performed using Kaplan-Meyer analyses on 131 patients. Only deaths from neoplasia were considered. A P value

Original languageEnglish
Pages (from-to)36-44
Number of pages9
Issue number1
Publication statusPublished - Jan 1 2013


  • classification
  • gastroenteric tract
  • neuroendocrine neoplasm
  • neuroendocrine tumors
  • prognosis
  • TNM
  • World Health Organization

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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