TY - JOUR
T1 - Gastroenteropancreatic neuroendocrine neoplasms and inflammation
T2 - A complex cross-talk with relevant clinical implications
AU - NIKE
AU - Vitale, Giovanni
AU - Carra, Silvia
AU - Ferraù, Francesco
AU - Guadagno, Elia
AU - Faggiano, Antongiulio
AU - Colao, Annamaria
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2019/12/23
Y1 - 2019/12/23
N2 - Neuroendocrine neoplasms (NENs) are a group of tumors originating from the neuroendocrine system. They mainly occur in the digestive system and the respiratory tract. It is well-know a strict interaction between neuroendocrine system and inflammation, which can play an important role in NEN carcinogenesis. Inflammatory mediators, which are produced by the tumor microenvironment, can favor cancer induction and progression, and can promote immune editing. On the other hand, a balanced immune system represents a relevant step in cancer prevention through the elimination of dysplastic and cancer cells. Therefore, an inflammatory response may be both pro- and anti-tumorigenic. In this review, we provide an overview concerning the complex interplay between inflammation and gastroenteropancreatic NENs, focusing on the tumorigenesis and clinical implications in these tumors.
AB - Neuroendocrine neoplasms (NENs) are a group of tumors originating from the neuroendocrine system. They mainly occur in the digestive system and the respiratory tract. It is well-know a strict interaction between neuroendocrine system and inflammation, which can play an important role in NEN carcinogenesis. Inflammatory mediators, which are produced by the tumor microenvironment, can favor cancer induction and progression, and can promote immune editing. On the other hand, a balanced immune system represents a relevant step in cancer prevention through the elimination of dysplastic and cancer cells. Therefore, an inflammatory response may be both pro- and anti-tumorigenic. In this review, we provide an overview concerning the complex interplay between inflammation and gastroenteropancreatic NENs, focusing on the tumorigenesis and clinical implications in these tumors.
U2 - 10.1016/j.critrevonc.2019.102840
DO - 10.1016/j.critrevonc.2019.102840
M3 - Review article
C2 - 31918344
VL - 146
SP - 102840
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
ER -