Gastroenteropancreatic (neuro)endocrine neoplasms: The histology report

Guido Rindi, C. Bordi, S. La Rosa, E. Solcia, Gianfranco Delle Fave

Research output: Contribution to journalArticle

Abstract

Based on the year 2000 World Health Organization (WHO) classification and the European Neuroendocrine Tumor Society (ENETS) grading and staging proposals, we here define the minimal guidelines for pathology reporting of (neuro)endocrine neoplasms. The macroscopical description is recommended according to standard procedures and the microscopical description according to recognized architectural and cytological features for endocrine lesions. Minimal diagnostic immunohistochemistry entails the use of chromogranin A, synaptophysin and Ki67. Other potentially useful tests are those for CD56 N-CAM, PGP 9.5 and hormones for diagnosis, the somatostatin receptor subtype 2 for potential radiodiagnostics and therapy, and transcription factors like TTF1 and CDX2, for site of origin. Grading definition is always mandatory as well as TNM staging for surgical specimens.

Original languageEnglish
JournalDigestive and Liver Disease
Volume43
Issue numberSUPPL. 4
DOIs
Publication statusPublished - Mar 2011

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Keywords

  • Carcinoid
  • ENETS
  • Gastroenteropancreatic tract
  • GIPAD report
  • Grading
  • Neuroendocrine tumor
  • Staging
  • TNM
  • WHO 2000

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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