TY - JOUR
T1 - Gastroesophageal reflux disease
T2 - Pathogenesis, symptoms and complications
AU - Cioffi, U.
AU - Rosso, L.
AU - De Simone, M.
PY - 1998/6
Y1 - 1998/6
N2 - The onset of GERD depends on several factors leading to a prolonged exposition of the esophageal mucosa to inflammatory agents. Various mechanisms play a role in different patients, but generally, decreased LES tone and delayed esophageal clearance are the major causes. Although pyrosis and regurgitation are the most frequent complaints, the patient may have different symptoms or can be asymptomatic. The symptoms are not necessarily correlated with damaged mucosa. Recognized complications caused by reflux include esophagitis, stricture, hemorrhage, Barrett's epithelium and ulceration, aspiration and respiratory implications. The severity of complications may be an important element in predicting whether the patient can be successfully treated medically or surgically. The exact knowledge of the pathogenesis is mandatory for carrying out the most effective treatment.
AB - The onset of GERD depends on several factors leading to a prolonged exposition of the esophageal mucosa to inflammatory agents. Various mechanisms play a role in different patients, but generally, decreased LES tone and delayed esophageal clearance are the major causes. Although pyrosis and regurgitation are the most frequent complaints, the patient may have different symptoms or can be asymptomatic. The symptoms are not necessarily correlated with damaged mucosa. Recognized complications caused by reflux include esophagitis, stricture, hemorrhage, Barrett's epithelium and ulceration, aspiration and respiratory implications. The severity of complications may be an important element in predicting whether the patient can be successfully treated medically or surgically. The exact knowledge of the pathogenesis is mandatory for carrying out the most effective treatment.
KW - Esophagus
KW - Gastroesophageal reflux
UR - http://www.scopus.com/inward/record.url?scp=0032087092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032087092&partnerID=8YFLogxK
M3 - Article
C2 - 9689835
AN - SCOPUS:0032087092
VL - 40
SP - 132
EP - 138
JO - Panminerva Medica
JF - Panminerva Medica
SN - 0031-0808
IS - 2
ER -