Gastrointestinal amyloidosis: A case of chronic diarrhoea

C. Fonnesu, M. Giovinale, E. Verrecchia, G. De Socio, C. Cerquaglia, V. Curigliano, A. Soriano, L. Obici, A. Grieco, L. Lauriola, G. Gasbarrini, Raffaele Manna

Research output: Contribution to journalArticle

Abstract

Amyloidosis is a rare disease caused by extracellular deposits of insoluble fibrillar proteins in various organs and tissues. There are different forms of amyloidosis distinguished by the type of protein fibrils, by the sites of deposition and by associated conditions. Gastrointestinal involvement is common both in primary and secondary amyloidosis, while isolated gastrointestinal amyloidosis is rare. We describe a case of AL amyloidosis with a gastrointestinal involvement and restrictive cardiomiopathy. A 64 year old woman came to our attention with a history of chronic diarrhoea and weight loss, associated with dysphagia, dry mouth, xerophtalmia, chronic gastritis and depression. Clinical diagnosis has been difficult because of aspecificity of symptoms that mimed other more common diseases, like gastro-paresis, epigastric discomfort, gastric or duodenal ulcers, perforation, malabsorption, intestinal pseudo-obstruction. There is an important risk of misunderstanding and diagnostic delay. Indeed in this patient a diagnosis of irritable colon syndrome was erroneously established two years before admission in our hospital. Therefore gastrointestinal amyloidosis should be considered among differential diagnoses of chronic diarrhoea and weight loss when other more common diseases have been excluded.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalEuropean Review for Medical and Pharmacological Sciences
Volume13
Issue numberSUPPL. 1
Publication statusPublished - Mar 2009

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Amyloidosis
Diarrhea
Weight Loss
Intestinal Pseudo-Obstruction
Irritable Bowel Syndrome
Paresis
Gastritis
Stomach Ulcer
Duodenal Ulcer
Deglutition Disorders
Rare Diseases
Mouth
Proteins
Differential Diagnosis

Keywords

  • Amyloidosis
  • Chronic diarrhoea
  • Malabsorption

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

Fonnesu, C., Giovinale, M., Verrecchia, E., De Socio, G., Cerquaglia, C., Curigliano, V., ... Manna, R. (2009). Gastrointestinal amyloidosis: A case of chronic diarrhoea. European Review for Medical and Pharmacological Sciences, 13(SUPPL. 1), 45-50.

Gastrointestinal amyloidosis : A case of chronic diarrhoea. / Fonnesu, C.; Giovinale, M.; Verrecchia, E.; De Socio, G.; Cerquaglia, C.; Curigliano, V.; Soriano, A.; Obici, L.; Grieco, A.; Lauriola, L.; Gasbarrini, G.; Manna, Raffaele.

In: European Review for Medical and Pharmacological Sciences, Vol. 13, No. SUPPL. 1, 03.2009, p. 45-50.

Research output: Contribution to journalArticle

Fonnesu, C, Giovinale, M, Verrecchia, E, De Socio, G, Cerquaglia, C, Curigliano, V, Soriano, A, Obici, L, Grieco, A, Lauriola, L, Gasbarrini, G & Manna, R 2009, 'Gastrointestinal amyloidosis: A case of chronic diarrhoea', European Review for Medical and Pharmacological Sciences, vol. 13, no. SUPPL. 1, pp. 45-50.
Fonnesu C, Giovinale M, Verrecchia E, De Socio G, Cerquaglia C, Curigliano V et al. Gastrointestinal amyloidosis: A case of chronic diarrhoea. European Review for Medical and Pharmacological Sciences. 2009 Mar;13(SUPPL. 1):45-50.
Fonnesu, C. ; Giovinale, M. ; Verrecchia, E. ; De Socio, G. ; Cerquaglia, C. ; Curigliano, V. ; Soriano, A. ; Obici, L. ; Grieco, A. ; Lauriola, L. ; Gasbarrini, G. ; Manna, Raffaele. / Gastrointestinal amyloidosis : A case of chronic diarrhoea. In: European Review for Medical and Pharmacological Sciences. 2009 ; Vol. 13, No. SUPPL. 1. pp. 45-50.
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