Abstract
Von Willebrand disease (VWD), the most common genetic bleeding disorder, is characterised by a quantitative or qualitative defect of von Willebrand factor (VWF). Patients with VWD suffer from mucocutaneous bleeding, of severity usually proportional to the degree of VWF defect. In particular, gastrointestinal bleeding associated with angiodysplasia is often a severe symptom of difficult management. This review focuses on the pathophysiology, diagnosis and treatment of VWD-associated gastrointestinal angiodysplasia and related bleeding.
Original language | English |
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Pages (from-to) | 427-431 |
Number of pages | 5 |
Journal | Thrombosis and Haemostasis |
Volume | 112 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Bleeding
- Gastrointestinal angiodysplasia
- Therapy
- Von Willebrand disease
ASJC Scopus subject areas
- Hematology
- Medicine(all)