Gastrointestinal angiodysplasia and bleeding in von willebrand disease

Massimo Franchini, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


Von Willebrand disease (VWD), the most common genetic bleeding disorder, is characterised by a quantitative or qualitative defect of von Willebrand factor (VWF). Patients with VWD suffer from mucocutaneous bleeding, of severity usually proportional to the degree of VWF defect. In particular, gastrointestinal bleeding associated with angiodysplasia is often a severe symptom of difficult management. This review focuses on the pathophysiology, diagnosis and treatment of VWD-associated gastrointestinal angiodysplasia and related bleeding.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalThrombosis and Haemostasis
Issue number3
Publication statusPublished - 2014


  • Bleeding
  • Gastrointestinal angiodysplasia
  • Therapy
  • Von Willebrand disease

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)


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