Gastrointestinal basidiobolomycosis: An emerging mycosis difficult to diagnose but curable. Case report and review of the literature

Maria Diletta Pezzani, Valentina Di Cristo, Carlo Parravicini, Angelica Sonzogni, Cristina Tonello, Marco Franzetti, Salvatore Sollima, Mario Corbellino, Massimo Galli, Laura Milazzo, Spinello Antinori

Research output: Contribution to journalReview article

Abstract

Background: Gastrointestinal basidiobolomycosis (GIB) is a rare mycosis affecting almost exclusively immunocompetent subjects. Methods: We describe a case of GIB caused by Basidiobolus ranarum in a 25-year-old Italian immunocompetent man resident in Ireland who presented a 2-month history of epigastric pain. Suspecting colon cancer he underwent a right hemicolectomy subsequently leading to a diagnosis of GIB by means of molecular biology. After surgery a 9-month therapy with itraconazole was employed with a good outcome. A review of medical literature regarding GIB cases published in the period 1964–2017 is presented. Results: One-hundred and two cases of GIB were included in this analysis. The disease was observed predominantly in male gender (74.5%) and children (41.2%). Abdominal pain was the single most common complaint (86.3%) followed by fever (40.2%) and evidence of an abdominal mass (30.4%). Peripheral blood eosinophilia was detected in 85.7% of cases. Most of the patients were diagnosed in Saudi Arabia (37.2%) followed by USA (21.6%) and Iran (20.6%). Surgery plus antifungal therapy was employed in the majority of patients (77.5%). An unfavourable outcome was documented globally in 18.6% of patients. Conclusions: GIB seems to be an emerging intestinal mycosis among immunocompetent patients living in the Middle East and Arizona.

Original languageEnglish
Article number101378
JournalTravel Medicine and Infectious Disease
Volume31
DOIs
Publication statusPublished - Sep 1 2019

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Keywords

  • Basidiobolomycosis
  • Emerging mycosis
  • Gastrointestinal infection
  • Italy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Pezzani, M. D., Di Cristo, V., Parravicini, C., Sonzogni, A., Tonello, C., Franzetti, M., Sollima, S., Corbellino, M., Galli, M., Milazzo, L., & Antinori, S. (2019). Gastrointestinal basidiobolomycosis: An emerging mycosis difficult to diagnose but curable. Case report and review of the literature. Travel Medicine and Infectious Disease, 31, [101378]. https://doi.org/10.1016/j.tmaid.2019.01.013