Gastrointestinal Mastocytosis: A Potential Diagnostic Pitfall to Be Aware.

Magda Zanelli, Rish K. Pai, Maria Grazia Zorzi, Maurizio Zizzo, Giovanni Martino, Luca Morelli, Alice Parisi, Loredana De Marco, Valerio Annessi, Stefano Ascani

Research output: Contribution to journalArticle

Abstract

Mastocytosis is a rare and heterogeneous group of disorders that may be limited to the skin and even spontaneously regress or may have a systemic presentation with multi-organ involvement and poor outcome. Among the extracutaneous sites, gastrointestinal tract is often affected, but nonspecific clinical manifestations combined with subtle histological findings of the disease makes the diagnosis of gastrointestinal mastocytosis rather hard. In absence of a high index of suspicion, gastrointestinal involvement is easily overlooked. We report a challenging case of systemic mastocytosis presenting with isolated gastrointestinal manifestations without skin involvement, in which the diagnosis was missed at first evaluation of intestinal biopsies.

Original languageEnglish
Pages (from-to)643-646
Number of pages4
JournalInternational Journal of Surgical Pathology
Volume27
Issue number6
DOIs
Publication statusPublished - Sep 1 2019

Keywords

  • endoscopy
  • gastrointestinal
  • mast cell
  • mastocytosis
  • tryptase

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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