Gastrointestinal Mastocytosis

A Potential Diagnostic Pitfall to Be Aware

Magda Zanelli, Rish K. Pai, Maria Grazia Zorzi, Maurizio Zizzo, Giovanni Martino, Luca Morelli, Alice Parisi, Loredana De Marco, Valerio Annessi, Stefano Ascani

Research output: Contribution to journalArticle

Abstract

Mastocytosis is a rare and heterogeneous group of disorders that may be limited to the skin and even spontaneously regress or may have a systemic presentation with multi-organ involvement and poor outcome. Among the extracutaneous sites, gastrointestinal tract is often affected, but nonspecific clinical manifestations combined with subtle histological findings of the disease makes the diagnosis of gastrointestinal mastocytosis rather hard. In absence of a high index of suspicion, gastrointestinal involvement is easily overlooked. We report a challenging case of systemic mastocytosis presenting with isolated gastrointestinal manifestations without skin involvement, in which the diagnosis was missed at first evaluation of intestinal biopsies.

Original languageEnglish
JournalInternational Journal of Surgical Pathology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Mastocytosis
Systemic Mastocytosis
Skin Manifestations
Gastrointestinal Tract
Biopsy
Skin

Keywords

  • endoscopy
  • gastrointestinal
  • mast cell
  • mastocytosis
  • tryptase

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Gastrointestinal Mastocytosis : A Potential Diagnostic Pitfall to Be Aware. / Zanelli, Magda; Pai, Rish K.; Grazia Zorzi, Maria; Zizzo, Maurizio; Martino, Giovanni; Morelli, Luca; Parisi, Alice; De Marco, Loredana; Annessi, Valerio; Ascani, Stefano.

In: International Journal of Surgical Pathology, 01.01.2019.

Research output: Contribution to journalArticle

Zanelli, M, Pai, RK, Grazia Zorzi, M, Zizzo, M, Martino, G, Morelli, L, Parisi, A, De Marco, L, Annessi, V & Ascani, S 2019, 'Gastrointestinal Mastocytosis: A Potential Diagnostic Pitfall to Be Aware', International Journal of Surgical Pathology. https://doi.org/10.1177/1066896919846648
Zanelli, Magda ; Pai, Rish K. ; Grazia Zorzi, Maria ; Zizzo, Maurizio ; Martino, Giovanni ; Morelli, Luca ; Parisi, Alice ; De Marco, Loredana ; Annessi, Valerio ; Ascani, Stefano. / Gastrointestinal Mastocytosis : A Potential Diagnostic Pitfall to Be Aware. In: International Journal of Surgical Pathology. 2019.
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